Epigenetic regulatory mechanisms in stress-induced behavior

Sumana Chakravarty, Salil Saurav Pathak, Swati Maitra, Nitin Khandelwal, Karisetty Bhanu Chandra, Arvind Kumar

Research output: Chapter in Book/Report/Conference proceedingChapter

24 Scopus citations


Stress response is considered to have adaptive value for organisms faced with stressful condition. Chronic stress however adversely affects the physiology and may lead to neuropsychiatric disorders. Repeated stressful events in animal models have been shown to cause long-lasting changes in neural circuitries at molecular, cellular, and physiological level, leading to disorders of mood as well as cognition. Molecular studies in recent years have implicated diverse epigenetic mechanisms, including histone modifications, DNA methylation, and noncoding RNAs, that underlie dysregulation of genes in the affected neural circuitries in chronic stress-induced pathophysiology. A review of the myriad epigenetic regulatory mechanisms associated with neural and behavioral responses in animal models of stress-induced neuropsychiatric disorders is presented here. The review also deals with clinical evidence of the epigenetic dysregulation of genes in psychiatric disorders where chronic stress appears to underlie the etiopathology.

Original languageEnglish (US)
Title of host publicationInternational Review of Neurobiology
PublisherAcademic Press Inc.
Number of pages38
StatePublished - 2014
Externally publishedYes

Publication series

NameInternational Review of Neurobiology
ISSN (Print)0074-7742

Bibliographical note

Funding Information:
This work is supported by the Department of Biotechnology (DBT) Centre of Excellence (COE) in Epigenetics grant to A. K. and Department of Science and Technology grant (SR/CSI/25/2009) to S. C. and A. K. A. K. and S. C. also acknowledge the support from CSIR network project BSC0115 (miND). S. S. P., S. M., N. K., K. B. C. would like to thank Council of Scientific and Industrial Research (CSIR) for their research fellowships. We thank Dr. Abhay Sharma, Scientist IGIB for his critical comments on the manuscript.


  • Chromatin remodeling
  • DNA methylation
  • Epigenetic regulatory mechanisms
  • Histone acetylation
  • Histone deacetylation
  • Histone demethylation
  • Histone methylation
  • Noncoding RNA
  • Stress-induced mood disorders


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