Epidermolyse nécrosante suraiguë de Lyell ou toxic epidermal necrolysis

Translated title of the contribution: Toxic epidermal necrolysis

Paul L. Bigliardi, Wassim Raffoul, Mette M. Berger

Research output: Contribution to journalReview articlepeer-review


The toxic epidermal necrolysis (TEN) is an immunologic reaction in the skin with apoptosis of keratinocytes: most cases are reactions against drugs. The main features of this reaction are a separation of the epidermis and erosions of the mucus membranes, associated with a reduction of the general condition with kidney and liver failure. This leads to problems similar to those observed in severely burned patients. The mortality high of patients with TEN can be reduced, if the responsible drug is immediately withdrawn and if the patient is treated in a specialized burns intensive care unit. The medical treatment to stop the chain reaction of apoptosis is still under discussion. Through a case report, this article will focus on the complexity of the treatment of patients with TEN and will point out the importance of a multidisciplinary approach.

Translated title of the contributionToxic epidermal necrolysis
Original languageFrench
Pages (from-to)1112-1118
Number of pages7
JournalRevue Medicale Suisse
Issue number109
StatePublished - May 2 2007


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