TY - JOUR
T1 - Epidermal growth factor receptor positivity in angiomyolipoma contiguous to renal cell carcinoma
T2 - Report of two cases with immunohistochemical analysis
AU - Amin, Khalid
AU - O'Neil, Maura F.
AU - Fan, G.
AU - McGregor, Douglas H.
PY - 2011/9/1
Y1 - 2011/9/1
N2 - Renal cell carcinoma (RCC) and angiomyolipoma (AML), usually unassociated, have occasionally been reported to coexist in the same person, usually in patients with tuberous sclerosis. We report two patients without tuberous sclerosis whose nephrectomy specimens contained renal cell carcinoma directly contiguous to AML in the same kidney. When immunohistochemical staining for epidermal growth factor receptor (EGFR) was performed on the RCCs, an interesting observation was made. The contiguous AMLs demonstrated strong positivity for EGFR, a feature not observed in isolated AMLs. The significance of this finding is unclear. Paracrine regulation may exist between these two closely adjacent tumors leading to synchronous high expression of EGFR in the AML adjacent to RCC, which may in turn affect the biologic behavior of these AMLs, compared to AMLs not associated with RCC.
AB - Renal cell carcinoma (RCC) and angiomyolipoma (AML), usually unassociated, have occasionally been reported to coexist in the same person, usually in patients with tuberous sclerosis. We report two patients without tuberous sclerosis whose nephrectomy specimens contained renal cell carcinoma directly contiguous to AML in the same kidney. When immunohistochemical staining for epidermal growth factor receptor (EGFR) was performed on the RCCs, an interesting observation was made. The contiguous AMLs demonstrated strong positivity for EGFR, a feature not observed in isolated AMLs. The significance of this finding is unclear. Paracrine regulation may exist between these two closely adjacent tumors leading to synchronous high expression of EGFR in the AML adjacent to RCC, which may in turn affect the biologic behavior of these AMLs, compared to AMLs not associated with RCC.
UR - https://www.scopus.com/pages/publications/79951877165
UR - https://www.scopus.com/pages/publications/79951877165#tab=citedBy
M3 - Article
C2 - 21325256
AN - SCOPUS:79951877165
SN - 0091-7370
VL - 41
SP - 56
EP - 60
JO - Annals of Clinical and Laboratory Science
JF - Annals of Clinical and Laboratory Science
IS - 1
ER -
