Epidemiology of childhood acute myeloid leukemia

Susan E. Puumala, Julie A. Ross, Richard Aplenc, Logan G. Spector

Research output: Contribution to journalReview article

60 Citations (Scopus)

Abstract

Although leukemia is the most common childhood cancer diagnosis, the subtype, acute myeloid leukemia (AML), is less common and fewer etiologic studies exist. This review summarizes the major risk factors for AML. We searched the literature using PubMed for articles on childhood AML and reviewed 180 articles. While few risk factors are definitive, we identified several with consistent evidence of a possible effect. Thorough analysis of genetic and epigenetic factors is missing from this literature and methodological issues are unresolved. Future studies should more closely examine causal mechanisms, improve exposure measurement, and include analysis using genetic and epigenetic factors.

Original languageEnglish (US)
Pages (from-to)728-733
Number of pages6
JournalPediatric Blood and Cancer
Volume60
Issue number5
DOIs
StatePublished - May 1 2013

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Acute Myeloid Leukemia
Epidemiology
Epigenomics
PubMed
Leukemia
Neoplasms

Keywords

  • Acute myeloid leukemia
  • Children
  • Epidemiology

Cite this

Epidemiology of childhood acute myeloid leukemia. / Puumala, Susan E.; Ross, Julie A.; Aplenc, Richard; Spector, Logan G.

In: Pediatric Blood and Cancer, Vol. 60, No. 5, 01.05.2013, p. 728-733.

Research output: Contribution to journalReview article

Puumala, Susan E. ; Ross, Julie A. ; Aplenc, Richard ; Spector, Logan G. / Epidemiology of childhood acute myeloid leukemia. In: Pediatric Blood and Cancer. 2013 ; Vol. 60, No. 5. pp. 728-733.
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