TY - JOUR
T1 - Epidemiology and Outcomes of Glomerular Diseases in Low- and Middle-Income Countries
AU - Ekrikpo, Udeme
AU - Obiagwu, Patience
AU - Chika-Onu, Ugochi
AU - Yadla, Manjusha
AU - Karam, Sabine
AU - Tannor, Elliot K.
AU - Bello, Aminu K.
AU - Okpechi, Ikechi G.
N1 - Funding Information:
Financial disclosure and conflict of interest statements: none.
Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2022/9
Y1 - 2022/9
N2 - Glomerular diseases account for a significant proportion of chronic kidney disease in low-income and middle-income countries (LMICs). The epidemiology of glomerulonephritis is characterized inadequately in LMICs, largely owing to unavailable nephropathology services or uncertainty of the safety of the kidney biopsy procedure. In contrast to high-income countries where IgA nephropathy is the dominant primary glomerular disease, focal segmental glomerulosclerosis is common in large populations across Latin America, Africa, Middle East, and South East Asia, while IgA nephropathy is common in Chinese populations. Despite having a high prevalence of known genetic and viral risk factors that trigger focal segmental glomerulosclerosis, membranoproliferative glomerulonephritis also is common in adults and children in some African countries. Treatment of glomerular diseases in adults and children in LMICs largely is dependent on corticosteroids in combination with other immunosuppressive therapy, which often is cyclophosphamide because of its ready availability and low cost of treatment, despite significant adverse effects. Partial and/or complete remission status reported from studies of glomerular disease subtypes vary across LMIC regions, with high rates of kidney failure, mortality, and disease, and treatment complications often reported. Improving the availability of nephropathology services and ensuring availability of specific therapies are key measures to improving glomerular disease outcomes in LMICs.
AB - Glomerular diseases account for a significant proportion of chronic kidney disease in low-income and middle-income countries (LMICs). The epidemiology of glomerulonephritis is characterized inadequately in LMICs, largely owing to unavailable nephropathology services or uncertainty of the safety of the kidney biopsy procedure. In contrast to high-income countries where IgA nephropathy is the dominant primary glomerular disease, focal segmental glomerulosclerosis is common in large populations across Latin America, Africa, Middle East, and South East Asia, while IgA nephropathy is common in Chinese populations. Despite having a high prevalence of known genetic and viral risk factors that trigger focal segmental glomerulosclerosis, membranoproliferative glomerulonephritis also is common in adults and children in some African countries. Treatment of glomerular diseases in adults and children in LMICs largely is dependent on corticosteroids in combination with other immunosuppressive therapy, which often is cyclophosphamide because of its ready availability and low cost of treatment, despite significant adverse effects. Partial and/or complete remission status reported from studies of glomerular disease subtypes vary across LMIC regions, with high rates of kidney failure, mortality, and disease, and treatment complications often reported. Improving the availability of nephropathology services and ensuring availability of specific therapies are key measures to improving glomerular disease outcomes in LMICs.
KW - IgA nephropathy
KW - LMICs
KW - Minimal change disease
KW - focal segmental glomerulosclerosis
KW - glomerulonephritis
KW - kidney biopsy
KW - lupus nephritis
KW - membranous nephropathy
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U2 - 10.1016/j.semnephrol.2023.151316
DO - 10.1016/j.semnephrol.2023.151316
M3 - Review article
C2 - 36773418
AN - SCOPUS:85147775386
SN - 0270-9295
VL - 42
JO - Seminars in nephrology
JF - Seminars in nephrology
IS - 5
M1 - 151316
ER -