Epidemiology and genetics of early onset colorectal cancer—African overview with a focus on Ethiopia

Chimaobi Anugwom, Grace Braimoh, Amir Sultan, Willie Mohammed Johnson, Jose D. Debes, Abdulsemed Mohammed

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Colorectal cancer (CRC) is a common cause of cancer-related death worldwide, with high rates of late diagnosis and increased mortality in sub-Saharan Africa. Furthermore, there is an alarming uptrend in the incidence of early onset colorectal cancer (EOCRC) across the globe, thus necessitating the need for early screening in general and special populations. There is, however, limited data available on the incidence and genetic characteristics of EOCRC from resource-poor countries, particularly Africa. Moreover, there is lack of clarity if recommendations and mechanisms proposed based on data from resource-rich countries applies to other regions of the world. In this review, we appraise the literature on EOCRC, its overall incidence, and genetic components as it pertains to sub-Saharan Africa. In addition, we highlight epidemiologic and epigenetic findings of our EOCRC cohort in Ethiopia.

Original languageEnglish (US)
Pages (from-to)28-33
Number of pages6
JournalSeminars in Oncology
Volume50
Issue number1-2
DOIs
StatePublished - Feb 1 2023

Bibliographical note

Funding Information:
Robert Wood Johnson Foundation, AFMDP, University of Minnesota Center for Global Health and Social Responsibility Global Health Seed Award to JDD.

Publisher Copyright:
© 2023 Elsevier Inc.

Keywords

  • Colorectal cancer
  • Early
  • Ethiopia

PubMed: MeSH publication types

  • Journal Article
  • Review
  • Research Support, Non-U.S. Gov't

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