Epidemiology and characteristics of Escherichia coli sequence type 131 (ST131) from long-term care facility residents colonized intestinally with fluoroquinolone-resistant Escherichia coli

Jennifer H. Han, Charles Garrigan, Brian Johnston, Irving Nachamkin, Connie Clabots, Warren B. Bilker, Evelyn Santana, Pam Tolomeo, Joel Maslow, Janice Myers, Lesley Carson, Ebbing Lautenbach, James R. Johnson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The objective of this study was to evaluate molecular and epidemiologic factors associated with Escherichia coli sequence type 131 (ST131) among long-term care facility (LTCF) residents who acquired gastrointestinal tract colonization with fluoroquinolone-resistant E. coli (FQREC). Colonizing isolates from 37 residents who newly developed FQREC colonization at three LTCFs from 2006 to 2008 were evaluated. Twenty-nine (78%) of 37 total FQREC colonizing isolates were ST131. Most ST131 isolates had a distinctive combination of gyrA and parC replacement mutations. The ST131 and non-ST131 isolates differed significantly for the prevalence of many individual virulence factors but not for the proportion that qualified molecularly as extraintestinal pathogenic E. coli (ExPEC) or aggregate virulence factor scores. E. coli ST131 was highly prevalent among LTCF residents with FQREC colonization. Future studies should determine the risk factors for infection among ST131-colonized residents, and assess the potential for increased transmissibility of ST131 in the long-term care setting.

Original languageEnglish (US)
Pages (from-to)275-280
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Volume87
Issue number3
DOIs
StatePublished - Mar 1 2017

Keywords

  • Escherichia coli
  • Long-term care
  • ST131

Fingerprint Dive into the research topics of 'Epidemiology and characteristics of Escherichia coli sequence type 131 (ST131) from long-term care facility residents colonized intestinally with fluoroquinolone-resistant Escherichia coli'. Together they form a unique fingerprint.

Cite this