Epidemiologic evaluation of calcium oxalate urolithiasis in dogs in the United States: 2010-2015

Research output: Contribution to journalArticle

Abstract

Background: Positive health implications of early recognition of calcium oxalate (CaOx) urolithiasis include increased opportunity for nonsurgical removal, early dietary modification to minimize urolith growth, early removal to avoid urinary obstruction, and early recognition of genetic and metabolic diseases before they contribute to additional morbidity. Objectives: To identify high- and low-risk dog breeds for CaOx uroliths and to determine the relationship of age and sex to the development of CaOx uroliths. Animals: Calcium oxalate urolith submissions between 2010 and 2015. Methods: A comparative cross-sectional study was conducted to identify high- and low-risk breeds for CaOx uroliths by comparing cases to multiple comparison groups. At-risk breeds were identified if odds ratios were significant (P value '.05) across all comparison groups. Results: Of 258 898 urolith submissions, 124 285 were CaOx. Calcium oxalate was identified in 212 breeds. Twelve breeds were identified as high-risk breeds, and 14 breeds were identified as low-risk breeds. All high-risk breeds were small dog breeds, and all low-risk breeds were medium to large dog breeds. Overall, the mean age ± standard deviation of the first CaOx urolith was 8.4 ± 2.8 years. Conclusions and Clinical Importance: To achieve the health benefits of preclinical evaluation, breeds at high risk for CaOx urolithiasis should be screened at 5 to 6 years of age, which is 2 to 3 years before likely development of clinical urolithiasis.

Original languageEnglish (US)
Pages (from-to)2090-2095
Number of pages6
JournalJournal of veterinary internal medicine
Volume33
Issue number5
DOIs
StatePublished - Sep 1 2019

Fingerprint

calcium oxalate
bladder calculi
Calcium Oxalate
Dogs
breeds
dogs
dog breeds
urolithiasis
Calcium Oxalate Nephrolithiasis
Diet Therapy
Inborn Genetic Diseases
Sexual Development
Urolithiasis
Metabolic Diseases
metabolic diseases
genetic disorders
Insurance Benefits
cross-sectional studies
odds ratio
morbidity

Keywords

  • North America
  • calculus
  • dog
  • epidemiology
  • risk factor

Cite this

@article{1fc45b163dd54f518a010e8471acf7a3,
title = "Epidemiologic evaluation of calcium oxalate urolithiasis in dogs in the United States: 2010-2015",
abstract = "Background: Positive health implications of early recognition of calcium oxalate (CaOx) urolithiasis include increased opportunity for nonsurgical removal, early dietary modification to minimize urolith growth, early removal to avoid urinary obstruction, and early recognition of genetic and metabolic diseases before they contribute to additional morbidity. Objectives: To identify high- and low-risk dog breeds for CaOx uroliths and to determine the relationship of age and sex to the development of CaOx uroliths. Animals: Calcium oxalate urolith submissions between 2010 and 2015. Methods: A comparative cross-sectional study was conducted to identify high- and low-risk breeds for CaOx uroliths by comparing cases to multiple comparison groups. At-risk breeds were identified if odds ratios were significant (P value '.05) across all comparison groups. Results: Of 258 898 urolith submissions, 124 285 were CaOx. Calcium oxalate was identified in 212 breeds. Twelve breeds were identified as high-risk breeds, and 14 breeds were identified as low-risk breeds. All high-risk breeds were small dog breeds, and all low-risk breeds were medium to large dog breeds. Overall, the mean age ± standard deviation of the first CaOx urolith was 8.4 ± 2.8 years. Conclusions and Clinical Importance: To achieve the health benefits of preclinical evaluation, breeds at high risk for CaOx urolithiasis should be screened at 5 to 6 years of age, which is 2 to 3 years before likely development of clinical urolithiasis.",
keywords = "North America, calculus, dog, epidemiology, risk factor",
author = "Vachira Hunprasit and Schreiner, {Pamela J} and Bender, {Jeff B} and Lulich, {Jody P}",
year = "2019",
month = "9",
day = "1",
doi = "10.1111/jvim.15613",
language = "English (US)",
volume = "33",
pages = "2090--2095",
journal = "Journal of Veterinary Internal Medicine",
issn = "0891-6640",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Epidemiologic evaluation of calcium oxalate urolithiasis in dogs in the United States

T2 - 2010-2015

AU - Hunprasit, Vachira

AU - Schreiner, Pamela J

AU - Bender, Jeff B

AU - Lulich, Jody P

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Background: Positive health implications of early recognition of calcium oxalate (CaOx) urolithiasis include increased opportunity for nonsurgical removal, early dietary modification to minimize urolith growth, early removal to avoid urinary obstruction, and early recognition of genetic and metabolic diseases before they contribute to additional morbidity. Objectives: To identify high- and low-risk dog breeds for CaOx uroliths and to determine the relationship of age and sex to the development of CaOx uroliths. Animals: Calcium oxalate urolith submissions between 2010 and 2015. Methods: A comparative cross-sectional study was conducted to identify high- and low-risk breeds for CaOx uroliths by comparing cases to multiple comparison groups. At-risk breeds were identified if odds ratios were significant (P value '.05) across all comparison groups. Results: Of 258 898 urolith submissions, 124 285 were CaOx. Calcium oxalate was identified in 212 breeds. Twelve breeds were identified as high-risk breeds, and 14 breeds were identified as low-risk breeds. All high-risk breeds were small dog breeds, and all low-risk breeds were medium to large dog breeds. Overall, the mean age ± standard deviation of the first CaOx urolith was 8.4 ± 2.8 years. Conclusions and Clinical Importance: To achieve the health benefits of preclinical evaluation, breeds at high risk for CaOx urolithiasis should be screened at 5 to 6 years of age, which is 2 to 3 years before likely development of clinical urolithiasis.

AB - Background: Positive health implications of early recognition of calcium oxalate (CaOx) urolithiasis include increased opportunity for nonsurgical removal, early dietary modification to minimize urolith growth, early removal to avoid urinary obstruction, and early recognition of genetic and metabolic diseases before they contribute to additional morbidity. Objectives: To identify high- and low-risk dog breeds for CaOx uroliths and to determine the relationship of age and sex to the development of CaOx uroliths. Animals: Calcium oxalate urolith submissions between 2010 and 2015. Methods: A comparative cross-sectional study was conducted to identify high- and low-risk breeds for CaOx uroliths by comparing cases to multiple comparison groups. At-risk breeds were identified if odds ratios were significant (P value '.05) across all comparison groups. Results: Of 258 898 urolith submissions, 124 285 were CaOx. Calcium oxalate was identified in 212 breeds. Twelve breeds were identified as high-risk breeds, and 14 breeds were identified as low-risk breeds. All high-risk breeds were small dog breeds, and all low-risk breeds were medium to large dog breeds. Overall, the mean age ± standard deviation of the first CaOx urolith was 8.4 ± 2.8 years. Conclusions and Clinical Importance: To achieve the health benefits of preclinical evaluation, breeds at high risk for CaOx urolithiasis should be screened at 5 to 6 years of age, which is 2 to 3 years before likely development of clinical urolithiasis.

KW - North America

KW - calculus

KW - dog

KW - epidemiology

KW - risk factor

UR - http://www.scopus.com/inward/record.url?scp=85071495576&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071495576&partnerID=8YFLogxK

U2 - 10.1111/jvim.15613

DO - 10.1111/jvim.15613

M3 - Article

C2 - 31471926

AN - SCOPUS:85071495576

VL - 33

SP - 2090

EP - 2095

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

IS - 5

ER -