Des enzymes pour bloquer la communication bactérienne, une alternative aux antibiotiques ?

Translated title of the contribution: Enzymes for disrupting bacterial communication, an alternative to antibiotics?

B. Rémy, L. Plener, M. Elias, D. Daudé, E. Chabrière

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Quorum sensing (QS) is used by bacteria to communicate and synchronize their actions according to the cell density. In this way, they produce and secrete in the surrounding environment small molecules dubbed autoinducers (AIs) that regulate the expression of certain genes. The phenotypic traits regulated by QS are diverse and include pathogenicity, biofilm formation or resistance to anti-microbial treatments. The strategy, aiming at disrupting QS, known as quorum quenching (QQ), has emerged to counteract bacterial virulence and involves QS-inhibitors (QSI) or QQ-enzymes degrading AIs. Differently from antibiotics, QQ aims at blocking cell signaling and does not alter bacterial survival. This considerably decreases the selection pressure as compared to bactericide treatments and may reduce the occurrence of resistance mechanisms. QQ-enzymes are particularly appealing as they may disrupt molecular QS-signal without entering the cell and in a catalytic way. This review covers several aspects of QQ-based medical applications and the potential subsequent emergence of resistance is discussed.

Translated title of the contributionEnzymes for disrupting bacterial communication, an alternative to antibiotics?
Original languageFrench
Pages (from-to)413-420
Number of pages8
JournalAnnales Pharmaceutiques Francaises
Volume74
Issue number6
DOIs
StatePublished - Nov 1 2016

Keywords

  • Bacterial virulence
  • Biofilm
  • Lactonase
  • Quorum quenching
  • Quorum sensing

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