TY - JOUR
T1 - Enzyme-mediated oscillatory drug release through hydrogel membranes
AU - Baker, John P.
AU - Siegel, Ronald S.
PY - 1995
Y1 - 1995
N2 - Implantable polymeric drug-delivery devices have been constructed to deliver drugs at well-defined rates. Currently, an oscillator is under development that is fueled by endogenous compounds and contains a variable-permeability membrane. In this paper, a simple theoretical model has been developed for the membrane oscillator, and results of simulations based on the model are discussed. Diffusion-cell studies have been performed with a variable-permeability poly(N-isopropyl-acrylamide-co-methacrylic acid) hydrogel membrane. Using glucose as a probe solute, the results show that lowering the pH induces hydrogel volume collapse and cessation of glucose permeation across the membrane.
AB - Implantable polymeric drug-delivery devices have been constructed to deliver drugs at well-defined rates. Currently, an oscillator is under development that is fueled by endogenous compounds and contains a variable-permeability membrane. In this paper, a simple theoretical model has been developed for the membrane oscillator, and results of simulations based on the model are discussed. Diffusion-cell studies have been performed with a variable-permeability poly(N-isopropyl-acrylamide-co-methacrylic acid) hydrogel membrane. Using glucose as a probe solute, the results show that lowering the pH induces hydrogel volume collapse and cessation of glucose permeation across the membrane.
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U2 - 10.1557/proc-394-119
DO - 10.1557/proc-394-119
M3 - Conference article
AN - SCOPUS:0029501150
SN - 0272-9172
VL - 394
SP - 119
EP - 130
JO - Materials Research Society Symposium - Proceedings
JF - Materials Research Society Symposium - Proceedings
T2 - Proceedings of the 1995 MRS Spring Meeting
Y2 - 17 April 1995 through 21 April 1995
ER -