Enzyme-catalyzed ring-opening polymerization of ε-caprolactone using alkyne functionalized initiators

Marcela Castano, Jukuan Zheng, Judit E. Puskas, Matthew L. Becker

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Well-defined poly(caprolactone)s were generated using alkyne-based initiating systems catalyzed by Candida antarctica Lipase B (CALB). Propargyl alcohol and 4-dibenzocyclooctynol (DIBO) were shown to efficiently initiate the polymerizations under metal free conditions and yielded 4 to 24 KDa polymers with relatively narrow molecular mass distribution. The alkyne bonds in the strained and unstrained initiating systems survived the polymerization conditions and the purification process. The resulting bonds can be sequentially functionalized post-polymerization using metal free and copper catalyzed click chemistry conditions.

Original languageEnglish (US)
Pages (from-to)1891-1896
Number of pages6
JournalPolymer Chemistry
Issue number6
StatePublished - Mar 21 2014
Externally publishedYes


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