Environmental digital pulsed force mode AFM and confocal raman microscopy in biomedical coatings research

G. Haugstad, K. Wormuth

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Controlled release of amorphous drug from a polymer matrix depends intimately upon the degree of mixing of drug and polymer, the susceptibility of the drug to crystallization, and the ability of the drug to dissolve and diffuse through water-swollen polymer. Ideally, characterization methods would follow these processes on the molecular level in situ and in real time. We move closer to this ideal state of characterization through application of two imaging methods: digital pulsed force mode atomic force microscopy (D-PFM AFM) and confocal Raman microscopy (CRM). We examine model spin-coated films (∼1 μm thick) containing the drug dexamethasone dispersed in poly(n-alkyl methacrylate) homopolymer and blend coatings. We report aqueous-immersion studies of surface and subsurface structural changes due to drug elution over time frames ranging from very fast (a few minutes) to slow (tens of hours).

Original languageEnglish (US)
Title of host publicationNanotechnology 2009
Subtitle of host publicationFabrication, Particles, Characterization, MEMS, Electronics and Photonics - Technical Proceedings of the 2009 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2009
Pages277-280
Number of pages4
StatePublished - Nov 26 2009
EventNanotechnology 2009: Fabrication, Particles, Characterization, MEMS, Electronics and Photonics - 2009 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2009 - Houston, TX, United States
Duration: May 3 2009May 7 2009

Publication series

NameNanotechnology 2009: Fabrication, Particles, Characterization, MEMS, Electronics and Photonics - Technical Proceedings of the 2009 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2009
Volume1

Other

OtherNanotechnology 2009: Fabrication, Particles, Characterization, MEMS, Electronics and Photonics - 2009 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2009
CountryUnited States
CityHouston, TX
Period5/3/095/7/09

Keywords

  • Atomic force microscopy
  • Biomedical coating
  • Drug elution
  • Polymer
  • Surface morphology

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