Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor

Robert J. Geraghty, Claude Krummenacher, Gary H. Cohen, Roselyn J. Eisenberg, Patricia G. Spear

Research output: Contribution to journalArticlepeer-review

720 Scopus citations

Abstract

A human member of the immunoglobulin superfamily was shown to mediate entry of several alphaherpesviruses, including herpes simplex viruses (HSV) 1 and 2, porcine pseudorabies virus (PRV), and bovine herpesvirus 1 (BHV-1). This membrane glycoprotein is poliovirus receptor-related protein 1 (Prr1), designated here as HveC. Incubation of HSV-1 with a secreted form of HveC inhibited subsequent infection of a variety of cell lines, suggesting that HveC interacts directly with the virus. Poliovirus receptor (Pvr) itself mediated entry of PRV and BHV-1 but not of the HSV strains tested. HveC was expressed in human cells of epithelial and neuronal origin; it is the prime candidate for the coreceptor that allows both HSV-1 and HSV-2 to infect epithelial cells on mucosal surfaces and spread to cells of the nervous system.

Original languageEnglish (US)
Pages (from-to)1618-1620
Number of pages3
JournalScience
Volume280
Issue number5369
DOIs
StatePublished - Jun 5 1998

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