TY - JOUR
T1 - Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor
AU - Geraghty, Robert J.
AU - Krummenacher, Claude
AU - Cohen, Gary H.
AU - Eisenberg, Roselyn J.
AU - Spear, Patricia G.
PY - 1998/6/5
Y1 - 1998/6/5
N2 - A human member of the immunoglobulin superfamily was shown to mediate entry of several alphaherpesviruses, including herpes simplex viruses (HSV) 1 and 2, porcine pseudorabies virus (PRV), and bovine herpesvirus 1 (BHV-1). This membrane glycoprotein is poliovirus receptor-related protein 1 (Prr1), designated here as HveC. Incubation of HSV-1 with a secreted form of HveC inhibited subsequent infection of a variety of cell lines, suggesting that HveC interacts directly with the virus. Poliovirus receptor (Pvr) itself mediated entry of PRV and BHV-1 but not of the HSV strains tested. HveC was expressed in human cells of epithelial and neuronal origin; it is the prime candidate for the coreceptor that allows both HSV-1 and HSV-2 to infect epithelial cells on mucosal surfaces and spread to cells of the nervous system.
AB - A human member of the immunoglobulin superfamily was shown to mediate entry of several alphaherpesviruses, including herpes simplex viruses (HSV) 1 and 2, porcine pseudorabies virus (PRV), and bovine herpesvirus 1 (BHV-1). This membrane glycoprotein is poliovirus receptor-related protein 1 (Prr1), designated here as HveC. Incubation of HSV-1 with a secreted form of HveC inhibited subsequent infection of a variety of cell lines, suggesting that HveC interacts directly with the virus. Poliovirus receptor (Pvr) itself mediated entry of PRV and BHV-1 but not of the HSV strains tested. HveC was expressed in human cells of epithelial and neuronal origin; it is the prime candidate for the coreceptor that allows both HSV-1 and HSV-2 to infect epithelial cells on mucosal surfaces and spread to cells of the nervous system.
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U2 - 10.1126/science.280.5369.1618
DO - 10.1126/science.280.5369.1618
M3 - Article
C2 - 9616127
AN - SCOPUS:0032486317
SN - 0036-8075
VL - 280
SP - 1618
EP - 1620
JO - Science
JF - Science
IS - 5369
ER -