Enterostatin inhibits insulin secretion from isolated perifused rat islets

C. Erlanson-Albertsson, B. Hering, R. G. Bretzel, K. Federlin

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16 Scopus citations

Abstract

The effect of enterostatin on glucose-induced insulin secretion was examined in isolated, perifused rat islets. In the presence of 16.67 mM glucose, there was significant inhibition of insulin secretion at concentrations of 200 nM, 2, 20 and 40 μM enterostatin. In particular, the second phase of insulin secretion was inhibited. With a low concentration of glucose (2.78 mM), there was no significant effect on insulin secretion by enterostatin. The inhibition of insulin secretion exerted by enterostatin may be an important effect in the prevention of insulin resistance.

Original languageEnglish (US)
Pages (from-to)160-163
Number of pages4
JournalActa Diabetologica
Volume31
Issue number3
DOIs
StatePublished - Sep 1 1994

Keywords

  • Insulin resistance
  • Pancreatic procolipase
  • Type 2 diabetes

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