Enterococcal peptide sex pheromones: Synthesis and control of biological activity

Josephine R. Chandler; Gary M Dunny

doi:10.1016/j.peptides.2003.10.020

Enterococcal peptide sex pheromones: Synthesis and control of biological activity

Josephine R. Chandler, Gary M Dunny

Microbiology

Research output: Contribution to journal › Review article › peer-review

66 Scopus citations

Abstract

The enterococcal pheromone-inducible plasmids such as pCF10 represent a unique class of mobile genetic elements whose transfer functions are induced by peptide sex pheromones. These pheromones are excreted by potential recipient cells and detected by plasmid-containing donor cells at the cell surface, where the pheromone is imported and signals induction of the plasmid transfer system. Pheromone is processed from a chromosomally encoded lipoprotein and excreted by both the donor and recipient cells, but a carefully controlled detection system prevents a response to self-pheromone while still allowing an extremely sensitive response to exogenous pheromone.

Original language	English (US)
Pages (from-to)	1377-1388
Number of pages	12
Journal	Peptides
Volume	25
Issue number	9
DOIs	https://doi.org/10.1016/j.peptides.2003.10.020
State	Published - Sep 2004

Bibliographical note

Funding Information:
The authors thank all of the members of the Dunny laboratory for providing much of the data on which this paper is based. This research is supported by NIH grant no. GM49530. J.R.C. is a trainee funded by the NIH MinnCResT training grant no. T32 DE07288.

Keywords

Enterococcus faecalis
Pheromone
Pheromone-inducible conjugative plasmid
PrgY
PrgZ
iCF10
pAD1
pCF10
pPD1

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title = "Enterococcal peptide sex pheromones: Synthesis and control of biological activity",

abstract = "The enterococcal pheromone-inducible plasmids such as pCF10 represent a unique class of mobile genetic elements whose transfer functions are induced by peptide sex pheromones. These pheromones are excreted by potential recipient cells and detected by plasmid-containing donor cells at the cell surface, where the pheromone is imported and signals induction of the plasmid transfer system. Pheromone is processed from a chromosomally encoded lipoprotein and excreted by both the donor and recipient cells, but a carefully controlled detection system prevents a response to self-pheromone while still allowing an extremely sensitive response to exogenous pheromone.",

keywords = "Enterococcus faecalis, Pheromone, Pheromone-inducible conjugative plasmid, PrgY, PrgZ, iCF10, pAD1, pCF10, pPD1",

author = "Chandler, {Josephine R.} and Dunny, {Gary M}",

note = "Funding Information: The authors thank all of the members of the Dunny laboratory for providing much of the data on which this paper is based. This research is supported by NIH grant no. GM49530. J.R.C. is a trainee funded by the NIH MinnCResT training grant no. T32 DE07288. ",

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doi = "10.1016/j.peptides.2003.10.020",

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AU - Dunny, Gary M

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PY - 2004/9

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N2 - The enterococcal pheromone-inducible plasmids such as pCF10 represent a unique class of mobile genetic elements whose transfer functions are induced by peptide sex pheromones. These pheromones are excreted by potential recipient cells and detected by plasmid-containing donor cells at the cell surface, where the pheromone is imported and signals induction of the plasmid transfer system. Pheromone is processed from a chromosomally encoded lipoprotein and excreted by both the donor and recipient cells, but a carefully controlled detection system prevents a response to self-pheromone while still allowing an extremely sensitive response to exogenous pheromone.

AB - The enterococcal pheromone-inducible plasmids such as pCF10 represent a unique class of mobile genetic elements whose transfer functions are induced by peptide sex pheromones. These pheromones are excreted by potential recipient cells and detected by plasmid-containing donor cells at the cell surface, where the pheromone is imported and signals induction of the plasmid transfer system. Pheromone is processed from a chromosomally encoded lipoprotein and excreted by both the donor and recipient cells, but a carefully controlled detection system prevents a response to self-pheromone while still allowing an extremely sensitive response to exogenous pheromone.

KW - Enterococcus faecalis

KW - Pheromone

KW - Pheromone-inducible conjugative plasmid

KW - PrgY

KW - PrgZ

KW - iCF10

KW - pAD1

KW - pCF10

KW - pPD1

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DO - 10.1016/j.peptides.2003.10.020

M3 - Review article

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SN - 0196-9781

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EP - 1388

JO - Peptides

JF - Peptides

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ER -

Enterococcal peptide sex pheromones: Synthesis and control of biological activity

Abstract

Bibliographical note

Keywords

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