Enterococcal peptide sex pheromones: Synthesis and control of biological activity

Josephine R. Chandler, Gary M Dunny

Research output: Contribution to journalReview article

54 Scopus citations

Abstract

The enterococcal pheromone-inducible plasmids such as pCF10 represent a unique class of mobile genetic elements whose transfer functions are induced by peptide sex pheromones. These pheromones are excreted by potential recipient cells and detected by plasmid-containing donor cells at the cell surface, where the pheromone is imported and signals induction of the plasmid transfer system. Pheromone is processed from a chromosomally encoded lipoprotein and excreted by both the donor and recipient cells, but a carefully controlled detection system prevents a response to self-pheromone while still allowing an extremely sensitive response to exogenous pheromone.

Original languageEnglish (US)
Pages (from-to)1377-1388
Number of pages12
JournalPeptides
Volume25
Issue number9
DOIs
StatePublished - Sep 1 2004

Keywords

  • Enterococcus faecalis
  • Pheromone
  • Pheromone-inducible conjugative plasmid
  • PrgY
  • PrgZ
  • iCF10
  • pAD1
  • pCF10
  • pPD1

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