Enigmatic roles of Mcm10 in DNA replication

Research output: Contribution to journalReview article

46 Citations (Scopus)

Abstract

Minichromosome maintenance protein 10 (Mcm10) is required for DNA replication in all eukaryotes. Although the exact contribution of Mcm10 to genome replication remains heavily debated, early reports suggested that it promotes DNA unwinding and origin firing. These ideas have been solidified by recent studies that propose a role for Mcm10 in helicase activation. Whereas the molecular underpinnings of this activation step have yet to be revealed, structural data on Mcm10 provide further insight into a possible mechanism of action. The essential role in DNA replication initiation is not mutually exclusive with additional functions that Mcm10 may have as part of the elongation machinery. Here, we review the recent findings regarding the role of Mcm10 in DNA replication and discuss existing controversies.

Original languageEnglish (US)
Pages (from-to)184-194
Number of pages11
JournalTrends in Biochemical Sciences
Volume38
Issue number4
DOIs
StatePublished - Apr 1 2013

Fingerprint

Minichromosome Maintenance Proteins
DNA Replication
DNA
Chemical activation
Eukaryota
Machinery
Elongation
Genes
Genome

Keywords

  • DNA replication
  • Double-strand breaks
  • Genome integrity
  • Mcm10
  • OB-fold
  • Replication forks
  • Zn-finger domains

Cite this

Enigmatic roles of Mcm10 in DNA replication. / Thu, Yee Mon; Bielinsky, Anja Katrin.

In: Trends in Biochemical Sciences, Vol. 38, No. 4, 01.04.2013, p. 184-194.

Research output: Contribution to journalReview article

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