Enhancing the predictive value of urinary albumin for diabetic nephropathy

Luiza Caramori, Paola Fioretto, Michael Mauer

Research output: Contribution to journalReview article

65 Citations (Scopus)

Abstract

Diabetic nephropathy (DN) is a growing cause of ESRD despite widely known recommendations for improved glycemic and BP control. Perhaps earlier identification of patients who have diabetes and are at high risk for DN could reverse these epidemiologic trends. Albumin excretion rate (AER), the mainstay of early detection of DN, is not a sufficiently precise predictor of DN risk. Careful family history, smoking history, consideration of absolute versus categorical AER values, more frequent AER measures, ambulatory BP monitoring, precise GFR measurements, diabetic retinopathy assessments, and plasma lipid levels all can add to predictive accuracy for DN. Thus, although further research in DN biomarkers and predictors is greatly needed, a careful integrated evaluation of currently available parameters can improve our ability to predict DN risk in individual patients.

Original languageEnglish (US)
Pages (from-to)339-352
Number of pages14
JournalJournal of the American Society of Nephrology
Volume17
Issue number2
DOIs
StatePublished - Feb 1 2006

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Diabetic Nephropathies
Albumins
Ambulatory Monitoring
Aptitude
Diabetic Retinopathy
Chronic Kidney Failure
Biomarkers
Smoking
History
Lipids
Research

Cite this

Enhancing the predictive value of urinary albumin for diabetic nephropathy. / Caramori, Luiza; Fioretto, Paola; Mauer, Michael.

In: Journal of the American Society of Nephrology, Vol. 17, No. 2, 01.02.2006, p. 339-352.

Research output: Contribution to journalReview article

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