Enhancing Psychosis-Spectrum Nosology Through an International Data Sharing Initiative

Anna R. Docherty, Eduardo Fonseca-Pedrero, Martin Debbané, Raymond C.K. Chan, Richard J. Linscott, Katherine G. Jonas, David C. Cicero, Melissa J. Green, Leonard J. Simms, Oliver Mason, David Watson, Ulrich Ettinger, Monika Waszczuk, Alexander Rapp, Phillip Grant, Roman Kotov, Colin G. DeYoung, Camilo J. Ruggero, Nicolas R. Eaton, Robert F. KruegerChristopher Patrick, Christopher Hopwood, F. Anthony O'Neill, David H. Zald, Christopher C. Conway, Daniel E. Adkins, Irwin D. Waldman, Jim Van Os, Patrick F. Sullivan, John S. Anderson, Andrey A. Shabalin, Scott R. Sponheim, Stephan F. Taylor, Rachel G. Grazioplene, Silviu A. Bacanu, Tim B. Bigdeli, Corinna Haenschel, Dolores Malaspina, Diane C. Gooding, Kristin Nicodemus, Frauke Schultze-Lutter, Neus Barrantes-Vidal, Christine Mohr, William T. Carpenter, Alex S. Cohen

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The latent structure of schizotypy and psychosis-spectrum symptoms remains poorly understood. Furthermore, molecular genetic substrates are poorly defined, largely due to the substantial resources required to collect rich phenotypic data across diverse populations. Sample sizes of phenotypic studies are often insufficient for advanced structural equation modeling approaches. In the last 50 years, efforts in both psychiatry and psychological science have moved toward (1) a dimensional model of psychopathology (eg, the current Hierarchical Taxonomy of Psychopathology [HiTOP] initiative), (2) an integration of methods and measures across traits and units of analysis (eg, the RDoC initiative), and (3) powerful, impactful study designs maximizing sample size to detect subtle genomic variation relating to complex traits (the Psychiatric Genomics Consortium [PGC]). These movements are important to the future study of the psychosis spectrum, and to resolving heterogeneity with respect to instrument and population. The International Consortium of Schizotypy Research is composed of over 40 laboratories in 12 countries, and to date, members have compiled a body of schizotypy-And psychosis-related phenotype data from more than 30000 individuals. It has become apparent that compiling data into a protected, relational database and crowdsourcing analytic and data science expertise will result in significant enhancement of current research on the structure and biological substrates of the psychosis spectrum. The authors present a data-sharing infrastructure similar to that of the PGC, and a resource-sharing infrastructure similar to that of HiTOP. This report details the rationale and benefits of the phenotypic data collective and presents an open invitation for participation.

Original languageEnglish (US)
Pages (from-to)S460-S467
JournalSchizophrenia bulletin
Volume44
DOIs
StatePublished - Oct 15 2018

Bibliographical note

Funding Information:
1Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT; 2Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA; 3Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, VA; 4Department of Psychiatry, Universidad de La Rioja, Oviedo, Spain; 5Research Department of Clinical, Educational, and Health Psychology, University College London, London, UK; 6Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland; 7Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; 8Department of Psychology, Chinese Academy of Sciences, Beijing, China; 9Department of Psychology, University of Otago, Dunedin, New Zealand; 10Department of Psychiatry, Stony Brook School of Medicine, Stony Brook, NY; 11Department of Psychology, University of Hawaii at Manoa, Honolulu, HI; 12School of Psychiatry, University of New South Wales, Sydney, Australia; 13Department of Psychology, University at Buffalo, The State University of New York, Buffalo, NY; 14Department of Psychology, University of Surrey, Guildford, UK; 15Department of Psychology, University of Notre Dame, Notre Dame, IN; 16Department of Psychology, University of Bonn, Bonn, Germany; 17Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany; 18Department of Psychology, Justus-Liebig-University Giessen, Giessen, Germany; 19Technische Hochschule Mittelhessen, University of Applied Sciences, Giessen, Germany; 20Department of Psychology, University of Minnesota, Minneapolis, MN; 21Department of Psychology, University of North Texas, Denton, TX; 22Department of Psychology, Stony Brook University, Stony Brook, NY; 23Department of Psychology, Florida State University, Tallahassee, FL; 24Department of Psychology, University of California—Davis, Davis, CA; 25Centre for Public Health, Institute of Clinical Sciences, Queen’s University Belfast, Belfast, UK; 26Department of Psychology, Vanderbilt University, Nashville, TN; 27Department of Psychiatry, Vanderbilt University, Nashville, TN; 28Department of Psychology, College of William & Mary, Williamsburg, VA; 29Department of Sociology, University of Utah, Salt Lake City, UT; 30Department of Psychology, Emory University, Atlanta, GA; 31Department of Psychiatry and Psychology, Maastricht University Medical Centre, Maastricht, The Netherlands; 32King’s Health Partners, Department of Psychosis Studies, Institute of Psychiatry, King’s College London, London, UK; 33Department of Psychiatry, Brain Center Rudolf Magnus Institute, University Medical Center, Utrecht, The Netherlands; 34Department of Psychiatry, University of North Carolina—Chapel Hill, Chapel Hill, NC; 35Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 36Department of Psychiatry, University of Michigan, Ann Arbor, MI; 37Department of Psychology, Yale University, New Haven, CT; 38Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, UK; 39Department of Psychology, City University, London, UK; 40Department of Psychiatry, Icahn School of Medicine, Mount Sinai, New York, NY; 41Department of Psychology, University of Wisconsin—Madison, Madison, WI; 42Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK; 43Department of Psychiatry and Psychotherapy, Heinrich-Heine University, Dusseldorf, Germany; 44Department of Clinical Psychology, Universitat Autònoma de Barcelona, Barcelona, Spain; 45Centre for Biomedical Research, University of North Carolina at Greensboro, Greensboro, NC; 46Sant Pere Claver—Fundació Sanitària, Barcelona, Spain; 47Institute of Psychology, University of Lausanne, Lausanne, Switzerland; 48Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD; 49Department of Psychology, Louisiana State University, Baton Rouge, LA

Publisher Copyright:
© The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Keywords

  • HiTOP
  • ICSR
  • data sharing
  • genetic
  • phenotype
  • psychosis
  • schizophrenia
  • schizotypal
  • schizotypy

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