Enhancement of antibody response of turkeys to trivalent avian influenza vaccine by positively charged liposomal avridine adjuvant

Olufemi O. Fatunmbi, John A. Newman, V. Sivanandan, David A Halvorson

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Trivalent avian influenza (AIV) antigens (H4N8, H5N2 and H7N3), mixed with positively charged, negatively charged and neutral avridine-containing liposomes, and oil-emulsion were subcutaneously administered to 6-week-old turkeys. Charged liposomal avridine adjuvant, either positive or negative, produced a better antibody response than uncharged liposomal avridine or oil-emulsion adjuvants when used in a trivalent avian influenza vaccine. The antibody response to the different antigens was generally greater to the positively charged adjuvanted vaccine compared with the negatively or neutral charged or oil-emulsion adjuvanted vaccines and these differences were significant (p < 0.05) with the three antigens. The results suggest that the positively charged liposomal avridine plays a significant role as adjuvant to the AIV antigens.

Original languageEnglish (US)
Pages (from-to)623-626
Number of pages4
JournalVaccine
Volume10
Issue number9
DOIs
StatePublished - 1992

Keywords

  • Influenza
  • liposomal avridine
  • serological response
  • surface charges
  • turkeys
  • vaccine

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