Enhancement of amphotericin b activity by a series of compounds related to phenolic antioxidants

Fred A. Andrews, George A. Sarosi, William H. Beggs

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Earlier studies showed that several common phenolic antioxidants enhanced the inhibitory action of amphotericin B against various species of yeasts. In the present work a search was made for compounds chemically related to the antioxidants which possess similar activity, greater water solubility, and which would present less of a potential toxicological hazard in the evaluation of drug-antioxidant combinations in vivo. A number of compounds showed these characteristics, the most interesting and potentially useful of which were L-dopa (L-β-3,4-dihydroxyphenylalanine) and dopamine (3,4-dihydroxyphenylethylamine).

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume5
Issue number2
DOIs
StatePublished - Mar 1979

Bibliographical note

Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.

Fingerprint Dive into the research topics of 'Enhancement of amphotericin b activity by a series of compounds related to phenolic antioxidants'. Together they form a unique fingerprint.

Cite this