Enhancement of afferent fiber activity in hippocampal slices

Walter C. Low; Spencer L. Bement

doi:10.1016/0006-8993(80)90763-5

Enhancement of afferent fiber activity in hippocampal slices

Walter C. Low, Spencer L. Bement

Neurosurgery

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The potentiation of synaptic activity in the hippocampal formation is a well documented phenomenon. It has been suggested, however, that a recruitment of additional afferent fibers can contribute to such an increase in synaptic activity. The hypothesis of an enhancement in afferent fiber activity, therefore, was investigated with the in vitro hippocampal slice preparation. Isolated radiatum fiber compound action potentials were evoked with paired electrical stimuli of equal intensity and separated in time by 30-40 msec. Statistical comparisons between control and test evoked responses reveal an augmentation of the test responses in support of the hypothesis of an enhancement in afferent fiber activity.

Original language	English (US)
Pages (from-to)	472-477
Number of pages	6
Journal	Brain Research
Volume	198
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(80)90763-5
State	Published - Oct 6 1980

Bibliographical note

Funding Information:
The invaluabled iscussionasn d programminags istancoef Dr. David White-horna reg ratefullay cknowledgeTdh. is work wass upportebdy a NIGMS predoctoral fellowshipG M 01289a nda Rackhamd issertatiognr antt o W.C.L., and by USPHS Grant NS 08470.

Keywords

hippocampus
potentiation
radiatum fibers

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10.1016/0006-8993(80)90763-5

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abstract = "The potentiation of synaptic activity in the hippocampal formation is a well documented phenomenon. It has been suggested, however, that a recruitment of additional afferent fibers can contribute to such an increase in synaptic activity. The hypothesis of an enhancement in afferent fiber activity, therefore, was investigated with the in vitro hippocampal slice preparation. Isolated radiatum fiber compound action potentials were evoked with paired electrical stimuli of equal intensity and separated in time by 30-40 msec. Statistical comparisons between control and test evoked responses reveal an augmentation of the test responses in support of the hypothesis of an enhancement in afferent fiber activity.",

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AU - Bement, Spencer L.

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PY - 1980/10/6

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N2 - The potentiation of synaptic activity in the hippocampal formation is a well documented phenomenon. It has been suggested, however, that a recruitment of additional afferent fibers can contribute to such an increase in synaptic activity. The hypothesis of an enhancement in afferent fiber activity, therefore, was investigated with the in vitro hippocampal slice preparation. Isolated radiatum fiber compound action potentials were evoked with paired electrical stimuli of equal intensity and separated in time by 30-40 msec. Statistical comparisons between control and test evoked responses reveal an augmentation of the test responses in support of the hypothesis of an enhancement in afferent fiber activity.

AB - The potentiation of synaptic activity in the hippocampal formation is a well documented phenomenon. It has been suggested, however, that a recruitment of additional afferent fibers can contribute to such an increase in synaptic activity. The hypothesis of an enhancement in afferent fiber activity, therefore, was investigated with the in vitro hippocampal slice preparation. Isolated radiatum fiber compound action potentials were evoked with paired electrical stimuli of equal intensity and separated in time by 30-40 msec. Statistical comparisons between control and test evoked responses reveal an augmentation of the test responses in support of the hypothesis of an enhancement in afferent fiber activity.

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KW - potentiation

KW - radiatum fibers

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Enhancement of afferent fiber activity in hippocampal slices

Abstract

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