Enhanced schwann cell attachment and alignment using one-pot "Dual Click" GRGDS and YIGSR derivatized nanofibers

Jukuan Zheng, Dimitria Kontoveros, Fei Lin, Geng Hua, Darrell H. Reneker, Matthew L. Becker, Rebecca K. Willits

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

(Figure Presented) Using metal-free click chemistry and oxime condensation methodologies, GRGDS and YIGSR peptides were coupled to random and aligned degradable nanofiber networks postelectrospinning in a one-pot reaction. The bound peptides are bioactive, as demonstrated by Schwann cell attachment and proliferation, and the inclusion of YIGSR with GRGDS alters the expression of the receptor for YIGSR. Additionally, aligned nanofibers act as a potential guidance cue by increasing the aspect ratio and aligning the actin filaments, which suggest that peptide-functionalized scaffolds would be useful to direct SCs for peripheral nerve regeneration.

Original languageEnglish (US)
Pages (from-to)357-363
Number of pages7
JournalBiomacromolecules
Volume16
Issue number1
DOIs
StatePublished - Jan 12 2015

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tyrosyl-isoleucyl-glycyl-seryl-arginine
glycyl-arginyl-glycyl-aspartyl-serine
Nanofibers
Peptides
Oximes
Scaffolds (biology)
Scaffolds
Actins
Aspect ratio
Condensation
Metals
Cells

Cite this

Zheng, J., Kontoveros, D., Lin, F., Hua, G., Reneker, D. H., Becker, M. L., & Willits, R. K. (2015). Enhanced schwann cell attachment and alignment using one-pot "Dual Click" GRGDS and YIGSR derivatized nanofibers. Biomacromolecules, 16(1), 357-363. https://doi.org/10.1021/bm501552t

Enhanced schwann cell attachment and alignment using one-pot "Dual Click" GRGDS and YIGSR derivatized nanofibers. / Zheng, Jukuan; Kontoveros, Dimitria; Lin, Fei; Hua, Geng; Reneker, Darrell H.; Becker, Matthew L.; Willits, Rebecca K.

In: Biomacromolecules, Vol. 16, No. 1, 12.01.2015, p. 357-363.

Research output: Contribution to journalArticle

Zheng, J, Kontoveros, D, Lin, F, Hua, G, Reneker, DH, Becker, ML & Willits, RK 2015, 'Enhanced schwann cell attachment and alignment using one-pot "Dual Click" GRGDS and YIGSR derivatized nanofibers', Biomacromolecules, vol. 16, no. 1, pp. 357-363. https://doi.org/10.1021/bm501552t
Zheng, Jukuan ; Kontoveros, Dimitria ; Lin, Fei ; Hua, Geng ; Reneker, Darrell H. ; Becker, Matthew L. ; Willits, Rebecca K. / Enhanced schwann cell attachment and alignment using one-pot "Dual Click" GRGDS and YIGSR derivatized nanofibers. In: Biomacromolecules. 2015 ; Vol. 16, No. 1. pp. 357-363.
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