Abstract
We report the short synthesis of novel C-nucleoside Remdesivir analogues, their cytotoxicity and an in vitro evaluation against SARS-CoV-2 (CoV2). The described compounds are nucleoside analogues bearing a nitrogen heterocycle as purine analogues. The hybrid structures described herein are designed to enhance the anti-CoV2 activity of Remdesivir. The compounds were evaluated for their cytotoxicity and their anti-CoV2 effect. We discuss the impact of combining both sugar and base modifications on the biological activities of these compounds, their lack of cytotoxicity and their antiviral efficacy.
Original language | English (US) |
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Article number | 2616 |
Journal | Molecules |
Volume | 28 |
Issue number | 6 |
DOIs | |
State | Published - Mar 2023 |
Bibliographical note
Publisher Copyright:© 2023 by the authors.
Keywords
- C-nucleoside
- SARS-CoV-2
- antiviral
- phosphate prodrug
PubMed: MeSH publication types
- Journal Article