Enhanced External Counterpulsation Improves Exercise Tolerance in Patients With Chronic Heart Failure

Arthur M. Feldman, Marc A. Silver, Gary S. Francis, Charles W. Abbottsmith, Bruce L. Fleishman, Ozlem Soran, Paul Andre de Lame, Thomas Varricchione

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62 Scopus citations

Abstract

Objectives: The PEECH (Prospective Evaluation of Enhanced External Counterpulsation in Congestive Heart Failure) study assessed the benefits of enhanced external counterpulsation (EECP) in the treatment of patients with mild-to-moderate heart failure (HF). Background: Enhanced external counterpulsation reduced angina symptoms and extended time to exercise-induced ischemia in patients with coronary artery disease, angina, and normal left ventricular function. A small pilot study and registry analysis suggested benefits in patients with HF. Methods: We randomized 187 subjects with mild-to-moderate symptoms of HF to either EECP and protocol-defined pharmacologic therapy (PT) or PT alone. Two co-primary end points were pre-defined: the percentage of subjects with a 60 s or more increase in exercise duration and the percentage of subjects with at least 1.25 ml/min/kg increase in peak volume of oxygen uptake (Vo2) at 6 months. Results: By the primary intent-to-treat analysis, 35% of subjects in the EECP group and 25% of control subjects increased exercise time by at least 60 s (p = 0.016) at 6 months. However, there was no between-group difference in peak Vo2 changes. New York Heart Association (NYHA) functional class improved in the active treatment group at 1 week (p < 0.01), 3 months (p < 0.02), and 6 months (p < 0.01). The Minnesota Living with Heart Failure score improved significantly 1 week (p < 0.02) and 3 months after treatment (p = 0.01). Conclusions: In this randomized, single-blinded study, EECP improved exercise tolerance, quality of life, and NYHA functional classification without an accompanying increase in peak Vo2.

Original languageEnglish (US)
Pages (from-to)1198-1205
Number of pages8
JournalJournal of the American College of Cardiology
Volume48
Issue number6
DOIs
StatePublished - Sep 19 2006

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    Feldman, A. M., Silver, M. A., Francis, G. S., Abbottsmith, C. W., Fleishman, B. L., Soran, O., de Lame, P. A., & Varricchione, T. (2006). Enhanced External Counterpulsation Improves Exercise Tolerance in Patients With Chronic Heart Failure. Journal of the American College of Cardiology, 48(6), 1198-1205. https://doi.org/10.1016/j.jacc.2005.10.079