Engulfment and killing capabilities of neutrophils and phagocytic splenic function in persons occupationally exposed to lead

Mary L S Queiroz, Fernando F. Costa, Claudia Bincoletto, Rita C R Perlingeiro, Denise C M Dantas, Mônica P. Cardoso, Mônica Almeida

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Phagocytosis and intracellular killing of Candida albicans and Candida pseudotropicalis by neutrophils as well as phagocytic splenic function from lead-exposed workers were studied. Two species of Candida were used since in individuals with myeloperoxidase deficiency neutrophils are unable to kill C. albicans, whereas C. pseudotropicalis can be effectively lysed. Phagocytosis with both antigens and phagocytic splenic function were normal in all the workers studied. However, lytic activity towards C. albicans, but not C. pseudotropicalis was impaired. This defect was observed in lead-exposed workers with blood lead levels and urinary delta-aminolevuliniv acid (ALA-U) concentrations in the "safe" (below 60 ug/dl and 6 mg/l, respectively) and toxic ranges. An impaired ability to kill C. albicans suggests that lead exposure may lead to a myeloperoxidase deficiency. With the exception of blood lead levels and ALA-U concentrations, there was no correlation between any of the other parameters examined.

Original languageEnglish (US)
Pages (from-to)239-244
Number of pages6
JournalInternational Journal of Immunopharmacology
Volume16
Issue number3
DOIs
StatePublished - Mar 1994

Fingerprint Dive into the research topics of 'Engulfment and killing capabilities of neutrophils and phagocytic splenic function in persons occupationally exposed to lead'. Together they form a unique fingerprint.

Cite this