Engineering of streptomyces platensis MA7339 for overproduction of platencin and congeners

Zhiguo Yu, Michael J. Smanski, Ryan M. Peterson, Karen Marchillo, David Andes, Scott R. Rajski, Ben Shen

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Abstract

Platensimycin (1) and platencin (2) are novel antibiotic leads against multidrug resistant pathogens. The production of 2 in Streptomyces platensis MA7339 is under the control of ptnR1, a GntR-like transcriptional regulator. Inactivating ptnR1 afforded S. platensis MA7339 mutant strain SB12600 that overproduces 2 at a titer -100-fold greater than that from the wild-type strain and accumulates platencin A1 (3) and eight new congeners, platencins A2-A9 (4-11). The isolation, structural elucidation, and antibacterial activity of 4-11, in comparison to 1-3, are described.

Original languageEnglish (US)
Pages (from-to)1744-1747
Number of pages4
JournalOrganic Letters
Volume12
Issue number8
DOIs
StatePublished - Apr 16 2010

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    Yu, Z., Smanski, M. J., Peterson, R. M., Marchillo, K., Andes, D., Rajski, S. R., & Shen, B. (2010). Engineering of streptomyces platensis MA7339 for overproduction of platencin and congeners. Organic Letters, 12(8), 1744-1747. https://doi.org/10.1021/ol100342m