Platensimycin (1) and platencin (2) are novel antibiotic leads against multidrug resistant pathogens. The production of 2 in Streptomyces platensis MA7339 is under the control of ptnR1, a GntR-like transcriptional regulator. Inactivating ptnR1 afforded S. platensis MA7339 mutant strain SB12600 that overproduces 2 at a titer -100-fold greater than that from the wild-type strain and accumulates platencin A1 (3) and eight new congeners, platencins A2-A9 (4-11). The isolation, structural elucidation, and antibacterial activity of 4-11, in comparison to 1-3, are described.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Apr 16 2010|