Engineering islets: Lessons from stem cells and embryonic development

Michelle J. Doyle, Lori Sussel

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


The attempts to understand pancreatic cell-type specification and apply this information to direct the differentiation of insulin-producing cells from various sources have produced significant advances in the past few years. The steady progress of ES and stem/progenitor cell isolation, growth, and manipulation, combined with new technologies for genetic manipulations and lineage tracing, and a greater understanding of the endogenous factors required for β-cell differentiation and expansion have made the identification of alternative sources of insulin-producing cells a possibility. These fields are still relatively young, however, continued collaboration efforts between researchers of many different scientific disciplines will allow the common goal of generating alternative sources of β cells for therapeutic purposes to be achieved.

Original languageEnglish (US)
Pages (from-to)149-162
Number of pages14
JournalEndocrinology and Metabolism Clinics of North America
Issue number1
StatePublished - Mar 2004

Bibliographical note

Funding Information:
Dr. Sussel is supported by the American Diabetes Association Career Development Award and National Institutes of Health (NIH) grant no. DK061248-0361. Michelle Doyle is supported by NIH grant no. T32-6M08730.


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