TY - JOUR
T1 - Engineering artificial metabolic pathways for biosynthesis
AU - Yu, Ping
AU - Tai, Yi Shu
AU - Woodruff, Adam P.
AU - Xiong, Mingyong
AU - Zhang, Kechun
N1 - Funding Information:
Prof. Ping Yu is supported by the National Natural Science Foundation of China (no. 31171658 ).
PY - 2012/11
Y1 - 2012/11
N2 - Increasing energy costs and environmental concerns have stimulated the development of sustainable approaches to the replacement of petrochemical processes. Metabolic engineering is a promising strategy that has enormous potential to produce bio-based products from simple, renewable, and inexpensive raw materials. Traditionally, biosynthesis is enabled by overexpressing product-specific enzymes or pathways in organisms that can be easily engineered. To expand the scope of fermentation products, there is a growing trend in designing artificial metabolic pathways through combinatorially screening or engineering enzymes from different sources into a single host. Here we review recent advances in the construction of novel biosynthetic routes, with a particular focus on ketoacid, fatty acid and isoprenoid pathways.
AB - Increasing energy costs and environmental concerns have stimulated the development of sustainable approaches to the replacement of petrochemical processes. Metabolic engineering is a promising strategy that has enormous potential to produce bio-based products from simple, renewable, and inexpensive raw materials. Traditionally, biosynthesis is enabled by overexpressing product-specific enzymes or pathways in organisms that can be easily engineered. To expand the scope of fermentation products, there is a growing trend in designing artificial metabolic pathways through combinatorially screening or engineering enzymes from different sources into a single host. Here we review recent advances in the construction of novel biosynthetic routes, with a particular focus on ketoacid, fatty acid and isoprenoid pathways.
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U2 - 10.1016/j.coche.2012.09.004
DO - 10.1016/j.coche.2012.09.004
M3 - Review article
AN - SCOPUS:84874106456
SN - 2211-3398
VL - 1
SP - 373
EP - 379
JO - Current Opinion in Chemical Engineering
JF - Current Opinion in Chemical Engineering
IS - 4
ER -