Engineering artificial metabolic pathways for biosynthesis

Ping Yu, Yi Shu Tai, Adam P. Woodruff, Mingyong Xiong, Kechun Zhang

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Increasing energy costs and environmental concerns have stimulated the development of sustainable approaches to the replacement of petrochemical processes. Metabolic engineering is a promising strategy that has enormous potential to produce bio-based products from simple, renewable, and inexpensive raw materials. Traditionally, biosynthesis is enabled by overexpressing product-specific enzymes or pathways in organisms that can be easily engineered. To expand the scope of fermentation products, there is a growing trend in designing artificial metabolic pathways through combinatorially screening or engineering enzymes from different sources into a single host. Here we review recent advances in the construction of novel biosynthetic routes, with a particular focus on ketoacid, fatty acid and isoprenoid pathways.

Original languageEnglish (US)
Pages (from-to)373-379
Number of pages7
JournalCurrent Opinion in Chemical Engineering
Issue number4
StatePublished - Nov 2012

Bibliographical note

Funding Information:
Prof. Ping Yu is supported by the National Natural Science Foundation of China (no. 31171658 ).

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