Engineering artificial metabolic pathways for biosynthesis

Ping Yu, Yi Shu Tai, Adam P. Woodruff, Mingyong Xiong, Kechun Zhang

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Increasing energy costs and environmental concerns have stimulated the development of sustainable approaches to the replacement of petrochemical processes. Metabolic engineering is a promising strategy that has enormous potential to produce bio-based products from simple, renewable, and inexpensive raw materials. Traditionally, biosynthesis is enabled by overexpressing product-specific enzymes or pathways in organisms that can be easily engineered. To expand the scope of fermentation products, there is a growing trend in designing artificial metabolic pathways through combinatorially screening or engineering enzymes from different sources into a single host. Here we review recent advances in the construction of novel biosynthetic routes, with a particular focus on ketoacid, fatty acid and isoprenoid pathways.

Original languageEnglish (US)
Pages (from-to)373-379
Number of pages7
JournalCurrent Opinion in Chemical Engineering
Volume1
Issue number4
DOIs
StatePublished - Nov 2012

Bibliographical note

Funding Information:
Prof. Ping Yu is supported by the National Natural Science Foundation of China (no. 31171658 ).

Fingerprint Dive into the research topics of 'Engineering artificial metabolic pathways for biosynthesis'. Together they form a unique fingerprint.

Cite this