Engineered swine models of cancer

Adrienne L. Watson, Daniel F. Carlson, David A. Largaespada, Perry B. Hackett, Scott C. Fahrenkrug

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Over the past decade, the technology to engineer genetically modified swine has seen many advancements, and because their physiology is remarkably similar to that of humans, swine models of cancer may be extremely valuable for preclinical safety studies as well as toxicity testing of pharmaceuticals prior to the start of human clinical trials. Hence, the benefits of using swine as a large animal model in cancer research and the potential applications and future opportunities of utilizing pigs in cancer modeling are immense. In this review, we discuss how pigs have been and can be used as a biomedical models for cancer research, with an emphasis on current technologies. We have focused on applications of precision genetics that can provide models that mimic human cancer predisposition syndromes. In particular, we describe the advantages of targeted gene-editing using custom endonucleases, specifically TALENs and CRISPRs, and transposon systems, to make novel pig models of cancer with broad preclinical applications.

Original languageEnglish (US)
Article number78
JournalFrontiers in Genetics
Volume7
Issue numberMAY
DOIs
StatePublished - May 9 2016

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Swine
Neoplasms
Clustered Regularly Interspaced Short Palindromic Repeats
Technology
Endonucleases
Research
Animal Models
Clinical Trials
Safety
Pharmaceutical Preparations

Keywords

  • Cancer genetics
  • Genetically engineered swine
  • Genome engineering
  • Preclinical cancer models
  • Swine models

Cite this

Engineered swine models of cancer. / Watson, Adrienne L.; Carlson, Daniel F.; Largaespada, David A.; Hackett, Perry B.; Fahrenkrug, Scott C.

In: Frontiers in Genetics, Vol. 7, No. MAY, 78, 09.05.2016.

Research output: Contribution to journalReview article

Watson, Adrienne L. ; Carlson, Daniel F. ; Largaespada, David A. ; Hackett, Perry B. ; Fahrenkrug, Scott C. / Engineered swine models of cancer. In: Frontiers in Genetics. 2016 ; Vol. 7, No. MAY.
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