Engaging neuroscience to advance translational research in brain barrier biology

Edward A. Neuwelt, Björn Bauer, Christoph Fahlke, Gert Fricker, Constantino Iadecola, Damir Janigro, Luc Leybaert, Zoltán Molnár, Martha E. O'Donnell, John T. Povlishock, Norman R. Saunders, Frank Sharp, Danica Stanimirovic, Ryan J. Watts, Lester R. Drewes

Research output: Contribution to journalReview articlepeer-review

365 Scopus citations

Abstract

The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and - when barrier integrity is impaired - in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.

Original languageEnglish (US)
Pages (from-to)169-182
Number of pages14
JournalNature Reviews Neuroscience
Volume12
Issue number3
DOIs
StatePublished - Mar 2011

Bibliographical note

Funding Information:
The meeting on which this report was based was partially funded by an R13 grant from the US National Institutes of Health (Grant 5 R13 CA086959-10). We would like to thank all of the people who attended the Engaging Neuroscience to Advance Brain Barriers Translational Research meeting (March 19–21, 2009), Gleneden Beach, Oregon, USA. Special thanks to Lester Drewes, Martha O’Donnell, Leslie Muldoon and Aliana Kim who were instrumental in the development of this report.

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