Endotoxin and prevention of hypoxic pulmonary vasoconstriction

Edward K Weir, Johannes Mlczoch, John T. Reeves, Robert F. Grover

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Endotoxin is known both to stimulate prostaglandin production and to abolish the pulmonary vascular pressor response to hypoxia. The present study demonstrated that two inhibitors of prostaglandin synthesis, meclofenamate and indomethacin, prevent loss of pulmonary vasoconstriction due to hypoxia when sublethal doses of endotoxin are administered. This suggests that endotoxin may stimulate the production of a dilator prostaglandin which would oppose the hypoxic vasoconstriction, but other ways in which these inhibitor drugs might act are considered. Endotoxin damages platelets and leukocytes, both of which can form prostaglandins and could be the source of a dilator prostaglandin. However, in these experiments endotoxin abolished the hypoxic pressor response in dogs rendered severely thrombocytopenic by platelet antiserum. This suggests that platelets are not involved. In further experiments blood from anesthetized dogs was circulated through glass bead columns. Changes in the leukocyte count following perfusion were correlated with changes in the subsequent pressor response to hypoxia. The possibility that leukocytes may be involved in the effect of endotoxin on the hypoxic pressor response is considered.

Original languageEnglish (US)
Pages (from-to)975-983
Number of pages9
JournalThe Journal of Laboratory and Clinical Medicine
Volume88
Issue number6
StatePublished - Jan 1 1976
Externally publishedYes

Fingerprint

Vasoconstriction
Endotoxins
Lung
Prostaglandins
Platelets
Blood Platelets
Leukocytes
Meclofenamic Acid
Dogs
Prostaglandin Antagonists
Leukocyte Count
Indomethacin
Glass
Blood Vessels
Immune Sera
Blood
Perfusion
Experiments
Pharmaceutical Preparations
Hypoxia

Cite this

Weir, E. K., Mlczoch, J., Reeves, J. T., & Grover, R. F. (1976). Endotoxin and prevention of hypoxic pulmonary vasoconstriction. The Journal of Laboratory and Clinical Medicine, 88(6), 975-983.

Endotoxin and prevention of hypoxic pulmonary vasoconstriction. / Weir, Edward K; Mlczoch, Johannes; Reeves, John T.; Grover, Robert F.

In: The Journal of Laboratory and Clinical Medicine, Vol. 88, No. 6, 01.01.1976, p. 975-983.

Research output: Contribution to journalArticle

Weir, EK, Mlczoch, J, Reeves, JT & Grover, RF 1976, 'Endotoxin and prevention of hypoxic pulmonary vasoconstriction', The Journal of Laboratory and Clinical Medicine, vol. 88, no. 6, pp. 975-983.
Weir, Edward K ; Mlczoch, Johannes ; Reeves, John T. ; Grover, Robert F. / Endotoxin and prevention of hypoxic pulmonary vasoconstriction. In: The Journal of Laboratory and Clinical Medicine. 1976 ; Vol. 88, No. 6. pp. 975-983.
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