Endotoxic damage to the stria vascularis: The pathogenesis of sensorineural hearing loss secondary to otitis media?

Yangchun Guc, Yiqin Wu, Wenlie Chen, Jizhen Lin

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

This study presents animal experiments on endotoxin (lipopolysaccharides: LPS) damage to the inner ear with special reference to the stria vascularis. The experimental group animals (albino guinea pigs) were injected with LPS into the perilymphatic space. Pyrogen-free saline (PFS) was injected into the control group. Strial structural evaluation and hearing tests were carried out before and one, three and five days after treatment. In PFS-treated (control) ears, no significant change was found either in hearing or structure. However, thresholds of Nl/P1 were elevated and latencies prolonged in LPS-treated ears. They had severe strial damage mainly to the cellular organelles. The mitochondria became swollen with a disordered, broken, degenerated or absent crest. Secondary lysosomes and autophagosomes increased in number with the presence of medulative inclusions. Na+-K+-ATPase reactant was obviously diminished. It is concluded that LPS-induced strial ototoxicity produces ion imbalance, causing changes in endolymph composition and energy failure in the organ of Corti and is also responsible for the pathogenesis of inner ear sequelae secondary to otitis media.

Original languageEnglish (US)
Pages (from-to)310-313
Number of pages4
JournalThe Journal of Laryngology & Otology
Volume108
Issue number4
DOIs
StatePublished - Apr 1994

Keywords

  • Hearing loss
  • Labyrinth
  • Otitis media
  • sensorineural
  • toxicity

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