Endothelium-independent dilation in children and adolescents

Kara L. Marlatt, Meghan C. McCue, Aaron S. Kelly, Andrea M. Metzig, Julia Steinberger, Donald R. Dengel

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Peak brachial artery dilation post-nitroglycerin (NTG) administration occurs between 3 and 5min in adults. The purpose of this study was to identify the time to peak dilation response to sublingual NTG (0·3mg) in youth. Endothelium-independent dilation (EID) was measured in 198 healthy (113 males, 85 females) youth (6-18years) via ultrasound imaging of the brachial artery following NTG administration. Time to peak EID was 268s following NTG administration, with no significant (P=0·6) difference between males and females. There was a significant (P<0·001) difference between EID post-NTG at the 3 versus 4min, 4 versus 5-min, and 3 versus 5min time points. Peak EID (males: 24·8±0·5 versus females: 25·3±0·6%, P=0·6) was not significantly different after accounting for baseline diameter. Peak response to NTG administration occurs between 4 and 5min. The results demonstrate the importance of measuring EID up to 5-min post-NTG administration in youth.

Original languageEnglish (US)
Pages (from-to)390-393
Number of pages4
JournalClinical Physiology and Functional Imaging
Issue number5
StatePublished - Sep 2011


  • Endothelium-independent dilation
  • Nitroglycerin
  • Smooth muscle
  • Ultrasound
  • Vascular function


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