Endothelial function in well-developed canine coronary collateral vessels

J. Altman, D. Dulas, T. Pavek, D. D. Laxson, D. C. Homans, R. J. Bache

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

This study examined responses of coronary collateral blood flow to endothelial-dependent vasodilators. Studies were performed in 13 dogs 4-6 mo after embolic occlusion of the left anterior descending coronary artery (LAD). Collateral flow was determined as the sum of retrograde flow from the cannulated LAD, and continuing tissue flow was measured with microspheres administered during the retrograde flow collection. Agonists were introduced into the left main coronary artery to reach collaterals arising from the left coronary arterial system. The endothelial-dependent vasodilators acetylcholine and bradykinin caused 21 ± 7 and 25 ± 8% increases of collateral flow, respectively (each P < 0.05). This was not different from the 28 ± 8% increase in collateral flow produced by nitroglycerin. To determine whether vasodilator prostaglandins contributed to the increased collateral flow, studies were performed after cyclooxygenase blockade with indomethacin (5 mg/kg iv). Indomethacin caused a 30 ± 9% decrease of retrograde flow during basal conditions but did not blunt the maximum collateral flow rates produced by acetylcholine, bradykinin, or nitroglycerin. These data demonstrate intact endothelial-dependent vasodilator mechanisms in the well-developed coronary collateral circulation.

Original languageEnglish (US)
Pages (from-to)H567-H572
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume264
Issue number2 33-2
DOIs
StatePublished - 1993

Keywords

  • acetylcholine
  • bradykinin
  • coronary occlusion
  • indomethacin
  • nitroglycerin

Fingerprint Dive into the research topics of 'Endothelial function in well-developed canine coronary collateral vessels'. Together they form a unique fingerprint.

  • Cite this