Endothelial dysfunction and cardiac allograft vasculopathy

Monica Colvin-Adams, Nonyelum O Harcourt, Daniel Duprez

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Cardiac allograft vasculopathy remains a major challenge to long-term survival after heart transplantation. Endothelial injury and dysfunction, as a result of multifactorial immunologic and nonimmunologic insults in the donor and the recipient, are prevalent early after transplant and may be precursors to overt cardiac allograft vasculopathy. Current strategies for managing cardiac allograft vasculopathy, however, rely on the identification and treatment of established disease. Improved understanding of mechanisms leading to endothelial dysfunction in heart transplant recipients may provide the foundation for the development of sensitive screening techniques and preventive therapies.

Original languageEnglish (US)
Pages (from-to)263-277
Number of pages15
JournalJournal of Cardiovascular Translational Research
Volume6
Issue number2
DOIs
StatePublished - Apr 1 2013

Keywords

  • Endothelial function
  • Heart transplant
  • Peripheral artery function
  • Transplant vasculopathy

Fingerprint Dive into the research topics of 'Endothelial dysfunction and cardiac allograft vasculopathy'. Together they form a unique fingerprint.

  • Cite this