Endothelial arginase II responds to pharmacological inhibition by elevation in protein level

Karina Krotova, Jawaharlal M. Patel, Edward R. Block, Sergey Zharikov

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Arginase is an enzyme which converts arginine to ornithine and urea. Recently, arginase has been implicated in many physiological and pathological processes including vascular diseases. Inhibition of arginase activity by pharmacological inhibitors is a useful tool to study the biology of arginases and their possible role in therapy. There are several arginase-specific inhibitors commercially available. Herein, we show that some of these inhibitors lead to an increase in arginase II protein level and activity. These effects should be anticipated when these inhibitors are in use or during the testing of new arginase inhibitors.

Original languageEnglish (US)
Pages (from-to)211-216
Number of pages6
JournalMolecular and cellular biochemistry
Volume343
Issue number1-2
DOIs
StatePublished - Oct 1 2010
Externally publishedYes

Keywords

  • Arginase
  • Arginase inhibitors
  • Endothelium

Fingerprint Dive into the research topics of 'Endothelial arginase II responds to pharmacological inhibition by elevation in protein level'. Together they form a unique fingerprint.

Cite this