Endophenotypes in psychiatric disease: Prospects and challenges

William G. Iacono

Research output: Contribution to journalComment/debatepeer-review

27 Scopus citations


Endophenotypes, quantitative neurobehavioral traits that index genetic susceptibility for a psychiatric disorder, have been examined in thousands of studies. Nevertheless, they have underexploited potential to provide etiological insights into prognosis, how psychopathology develops, the etiology of comorbidity, and the mechanisms of gene function.

Original languageEnglish (US)
Article number11
JournalGenome medicine
Issue number1
StatePublished - Feb 22 2018

Bibliographical note

Funding Information:
Salary support was provided by National Institute on Drug Abuse grants DA005147 and DA036216

Publisher Copyright:
© 2018 The Author(s).


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