Endoneurial blood supply to peripheral nerves is not uniform

Hitoshi Kozu, Eiji Tamura, Gareth J. Parry

Research output: Contribution to journalArticle

18 Scopus citations


Peripheral nerves are not uniformly susceptible to the effects of ischemia in human and experimental ischemic neuropathies. Since endoneurial blood flow is directly proportional to the number of endoneurial capillaries, we studied endoneurial capillary density at multiple levels of the peripheral nerves of normal rats. Capillary density was lowest in the sciatic and proximal tibial nerves and significantly higher in dorsal and ventral roots and distal tibial and plantar nerves. Endoneurial capillary density corresponds to the hierarchy of susceptibility to ischemic nerve damage in human and experimental ischemic neuropathies. These findings suggest that susceptibility of peripheral nerves to ischemia is determined, at least in part, by the density of endoneuriaI capillaries.

Original languageEnglish (US)
Pages (from-to)204-208
Number of pages5
JournalJournal of the Neurological Sciences
Issue number2
StatePublished - Sep 1992


  • Endoneurial capillaries
  • Ischemic neuropathy
  • Nerve blood flow
  • Vasa nervorum

Fingerprint Dive into the research topics of 'Endoneurial blood supply to peripheral nerves is not uniform'. Together they form a unique fingerprint.

  • Cite this