Endoneurial blood supply to peripheral nerves is not uniform

Hitoshi Kozu; Eiji Tamura; Gareth J. Parry

doi:10.1016/0022-510X(92)90070-2

Endoneurial blood supply to peripheral nerves is not uniform

Hitoshi Kozu, Eiji Tamura, Gareth J. Parry

Neurology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Peripheral nerves are not uniformly susceptible to the effects of ischemia in human and experimental ischemic neuropathies. Since endoneurial blood flow is directly proportional to the number of endoneurial capillaries, we studied endoneurial capillary density at multiple levels of the peripheral nerves of normal rats. Capillary density was lowest in the sciatic and proximal tibial nerves and significantly higher in dorsal and ventral roots and distal tibial and plantar nerves. Endoneurial capillary density corresponds to the hierarchy of susceptibility to ischemic nerve damage in human and experimental ischemic neuropathies. These findings suggest that susceptibility of peripheral nerves to ischemia is determined, at least in part, by the density of endoneuriaI capillaries.

Original language	English (US)
Pages (from-to)	204-208
Number of pages	5
Journal	Journal of the Neurological Sciences
Volume	111
Issue number	2
DOIs	https://doi.org/10.1016/0022-510X(92)90070-2
State	Published - Sep 1992

Bibliographical note

Funding Information:
AcknowledgemenTthsi s work was supported in partb y grants from the JuvenileD iabetesF oundation International and the American Medical Association, Education and ResearchF oundationM. ark Hurry provided invaluable technical assistance.

Keywords

Endoneurial capillaries
Ischemic neuropathy
Nerve blood flow
Vasa nervorum

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10.1016/0022-510X(92)90070-2

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title = "Endoneurial blood supply to peripheral nerves is not uniform",

abstract = "Peripheral nerves are not uniformly susceptible to the effects of ischemia in human and experimental ischemic neuropathies. Since endoneurial blood flow is directly proportional to the number of endoneurial capillaries, we studied endoneurial capillary density at multiple levels of the peripheral nerves of normal rats. Capillary density was lowest in the sciatic and proximal tibial nerves and significantly higher in dorsal and ventral roots and distal tibial and plantar nerves. Endoneurial capillary density corresponds to the hierarchy of susceptibility to ischemic nerve damage in human and experimental ischemic neuropathies. These findings suggest that susceptibility of peripheral nerves to ischemia is determined, at least in part, by the density of endoneuriaI capillaries.",

keywords = "Endoneurial capillaries, Ischemic neuropathy, Nerve blood flow, Vasa nervorum",

author = "Hitoshi Kozu and Eiji Tamura and Parry, {Gareth J.}",

note = "Funding Information: AcknowledgemenTthsi s work was supported in partb y grants from the JuvenileD iabetesF oundation International and the American Medical Association, Education and ResearchF oundationM. ark Hurry provided invaluable technical assistance.",

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AU - Kozu, Hitoshi

AU - Tamura, Eiji

AU - Parry, Gareth J.

N1 - Funding Information: AcknowledgemenTthsi s work was supported in partb y grants from the JuvenileD iabetesF oundation International and the American Medical Association, Education and ResearchF oundationM. ark Hurry provided invaluable technical assistance.

PY - 1992/9

Y1 - 1992/9

N2 - Peripheral nerves are not uniformly susceptible to the effects of ischemia in human and experimental ischemic neuropathies. Since endoneurial blood flow is directly proportional to the number of endoneurial capillaries, we studied endoneurial capillary density at multiple levels of the peripheral nerves of normal rats. Capillary density was lowest in the sciatic and proximal tibial nerves and significantly higher in dorsal and ventral roots and distal tibial and plantar nerves. Endoneurial capillary density corresponds to the hierarchy of susceptibility to ischemic nerve damage in human and experimental ischemic neuropathies. These findings suggest that susceptibility of peripheral nerves to ischemia is determined, at least in part, by the density of endoneuriaI capillaries.

AB - Peripheral nerves are not uniformly susceptible to the effects of ischemia in human and experimental ischemic neuropathies. Since endoneurial blood flow is directly proportional to the number of endoneurial capillaries, we studied endoneurial capillary density at multiple levels of the peripheral nerves of normal rats. Capillary density was lowest in the sciatic and proximal tibial nerves and significantly higher in dorsal and ventral roots and distal tibial and plantar nerves. Endoneurial capillary density corresponds to the hierarchy of susceptibility to ischemic nerve damage in human and experimental ischemic neuropathies. These findings suggest that susceptibility of peripheral nerves to ischemia is determined, at least in part, by the density of endoneuriaI capillaries.

KW - Endoneurial capillaries

KW - Ischemic neuropathy

KW - Nerve blood flow

KW - Vasa nervorum

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Endoneurial blood supply to peripheral nerves is not uniform

Abstract

Bibliographical note

Keywords

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