Peripheral nerves are not uniformly susceptible to the effects of ischemia in human and experimental ischemic neuropathies. Since endoneurial blood flow is directly proportional to the number of endoneurial capillaries, we studied endoneurial capillary density at multiple levels of the peripheral nerves of normal rats. Capillary density was lowest in the sciatic and proximal tibial nerves and significantly higher in dorsal and ventral roots and distal tibial and plantar nerves. Endoneurial capillary density corresponds to the hierarchy of susceptibility to ischemic nerve damage in human and experimental ischemic neuropathies. These findings suggest that susceptibility of peripheral nerves to ischemia is determined, at least in part, by the density of endoneuriaI capillaries.
Bibliographical noteFunding Information:
AcknowledgemenTthsi s work was supported in partb y grants from the JuvenileD iabetesF oundation International and the American Medical Association, Education and ResearchF oundationM. ark Hurry provided invaluable technical assistance.
- Endoneurial capillaries
- Ischemic neuropathy
- Nerve blood flow
- Vasa nervorum