Endometrial biopsies during treatment with subcutaneous pulsatile gonadotropin-releasing hormone and luteal-phase human chorionic gonadotropin

B. F. Campbell, Bill Phipps, T. C. Nagel, G. E. Tagatz

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A high incidence of luteal phase defect (LPD) has been reported using subcutaneous pulsatile gonadotropin-releasing hormone for induction of ovulation. We reviewed all patients treated with the combination of subcutaneous pulsatile gonadotropin-releasing hormone during the follicular phase and human chorionic gonadotropin during the luteal phase (GnRH-hCG) who underwent endometrial biopsy during a treatment cycle. All of these patients had biopsy-proven LPD which persited despite traditional therapy with progesterone vaginal suppositories and/or clomiphene citrate. The mean number of biopsies out of phase per patient prior to GnRH-hCG treatment was 2.8 ± 0.2 (± SEM). When treated with GnRH-hCG, 15/16 patients (94%) showed a normal endometrial biopsy. The probability of this result occurring by chance alone allowing for a 50% treatment independent correction rate is <.001. These results show that the combination of subcutaneous pulsatile gonadotropin-releasing hormone and luteal-phase human chorionic gonadotropin can result in normal endometrial maturation in a high percentage of cycles when administered as described. It appears in normal endometrial maturation in a high percentage of cyles when administered as described. It appears to be an effective alternative to traditional treatment modalities for luteal phase defect should one be needed.

Original languageEnglish (US)
Pages (from-to)329-333
Number of pages5
JournalInternational Journal of Fertility
Volume33
Issue number5
StatePublished - Jan 1 1988

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