Endolymphatic sac enhancement: Reversal of pathogenesis

Michael M. Paparella, Manuela Fina

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


As this article and many other publications have indicated, many thousands of patients with incapacitating intractable progressive Meniere's disease have had their lives restored through endolymphatic sac enhancement surgery. This is the only nondestructive procedure for Meniere's disease that has stood the test of time. Destructive procedures such as labyrinthectomy (chemical or physical) and vestibular nerve section are reserved for rare cases of failure or recurrence after sac enhancement, despite revision of the enhancement. There is much evidence to support the concept that endolymphatic sac enhancement reverses or enhances the pathogenesis of Meniere's disease. With additional clinical and molecular biologic research, endolymphatic sac enhancement will continue to improve and become more efficacious in the new millennium.

Original languageEnglish (US)
Pages (from-to)621-637
Number of pages17
JournalOtolaryngologic Clinics of North America
Issue number3
StatePublished - Jun 2002
Externally publishedYes


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