TY - JOUR
T1 - Endolymphatic sac enhancement
T2 - Reversal of pathogenesis
AU - Paparella, Michael M.
AU - Fina, Manuela
PY - 2002/6
Y1 - 2002/6
N2 - As this article and many other publications have indicated, many thousands of patients with incapacitating intractable progressive Meniere's disease have had their lives restored through endolymphatic sac enhancement surgery. This is the only nondestructive procedure for Meniere's disease that has stood the test of time. Destructive procedures such as labyrinthectomy (chemical or physical) and vestibular nerve section are reserved for rare cases of failure or recurrence after sac enhancement, despite revision of the enhancement. There is much evidence to support the concept that endolymphatic sac enhancement reverses or enhances the pathogenesis of Meniere's disease. With additional clinical and molecular biologic research, endolymphatic sac enhancement will continue to improve and become more efficacious in the new millennium.
AB - As this article and many other publications have indicated, many thousands of patients with incapacitating intractable progressive Meniere's disease have had their lives restored through endolymphatic sac enhancement surgery. This is the only nondestructive procedure for Meniere's disease that has stood the test of time. Destructive procedures such as labyrinthectomy (chemical or physical) and vestibular nerve section are reserved for rare cases of failure or recurrence after sac enhancement, despite revision of the enhancement. There is much evidence to support the concept that endolymphatic sac enhancement reverses or enhances the pathogenesis of Meniere's disease. With additional clinical and molecular biologic research, endolymphatic sac enhancement will continue to improve and become more efficacious in the new millennium.
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U2 - 10.1016/S0030-6665(02)00022-1
DO - 10.1016/S0030-6665(02)00022-1
M3 - Review article
C2 - 12486844
AN - SCOPUS:0036620748
SN - 0030-6665
VL - 35
SP - 621
EP - 637
JO - Otolaryngologic Clinics of North America
JF - Otolaryngologic Clinics of North America
IS - 3
ER -