Abstract
Thyrotropin-releasing hormone (TRH) administered intraventricularly (ICV) to rats causes a dose-dependent increase in gastric acid secretion over a range of 0.01 μg to 10 μg in the pyloris ligated rat. The maximum increase in gastric acid secretion occurs in the first hour. This effect of TRH is not mediated by its metabolites, histidyl-proline diketopiperazine or pyroglutamyl-histidyl-proline (acid TRH). β-endorphin, D-alanine-methionine-enkephalin and the leucine-enkephalin precursor, dynorphin, all inhibit TRH-induced gastric acid secretion. Bombesin, which reduces basal gastric acid secretion had no effect on TRH-induced secretion.
Original language | English (US) |
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Pages (from-to) | 293-297 |
Number of pages | 5 |
Journal | Life Sciences |
Volume | 29 |
Issue number | 3 |
DOIs | |
State | Published - Jul 20 1981 |
Bibliographical note
Funding Information:We thank Sandra Lindblatt, Julie Kneip and Harriet Acker for excellent technical assistance and JoAnn Tallman for secretarial assistance. These studies were supported by funds provided by the Veterans Administration.