Endogenous opiates inhibit gastric acid secretion induced by central administration of Thyrotropin-Releasing Hormone (TRH)

John E. Morley, Allen S Levine, Stephan E. Silvis

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Thyrotropin-releasing hormone (TRH) administered intraventricularly (ICV) to rats causes a dose-dependent increase in gastric acid secretion over a range of 0.01 μg to 10 μg in the pyloris ligated rat. The maximum increase in gastric acid secretion occurs in the first hour. This effect of TRH is not mediated by its metabolites, histidyl-proline diketopiperazine or pyroglutamyl-histidyl-proline (acid TRH). β-endorphin, D-alanine-methionine-enkephalin and the leucine-enkephalin precursor, dynorphin, all inhibit TRH-induced gastric acid secretion. Bombesin, which reduces basal gastric acid secretion had no effect on TRH-induced secretion.

Original languageEnglish (US)
Pages (from-to)293-297
Number of pages5
JournalLife Sciences
Volume29
Issue number3
DOIs
StatePublished - Jul 20 1981

Fingerprint Dive into the research topics of 'Endogenous opiates inhibit gastric acid secretion induced by central administration of Thyrotropin-Releasing Hormone (TRH)'. Together they form a unique fingerprint.

Cite this