Endogenous opiates and stress ulceration

John E. Morley, Allen S. Levine, Stephen E. Silvis

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Parenteral administration of the opiate antagonist, naltrexone, had a cytoprotective effect against stress-induced ulceration. This effect appears to be due to blockade of peripheral rather than central endogenous opiates and is not related to the central inhibitory effect of opiates on gastric acid secretion. Opiates have complex effects on gastric mucosal blood flow which may explain their role in stress ulceration.

Original languageEnglish (US)
Pages (from-to)693-699
Number of pages7
JournalLife Sciences
Volume31
Issue number7
DOIs
StatePublished - Aug 16 1982

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