Endogenous opiates and stress ulceration

John E. Morley, Allen S. Levine, Stephen E. Silvis

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Parenteral administration of the opiate antagonist, naltrexone, had a cytoprotective effect against stress-induced ulceration. This effect appears to be due to blockade of peripheral rather than central endogenous opiates and is not related to the central inhibitory effect of opiates on gastric acid secretion. Opiates have complex effects on gastric mucosal blood flow which may explain their role in stress ulceration.

Original languageEnglish (US)
Pages (from-to)693-699
Number of pages7
JournalLife Sciences
Issue number7
StatePublished - Aug 16 1982

Bibliographical note

Funding Information:
We thank Julie Knelp and Martha Grace for technical assistance and JoAnn Tallman for secretarial assistance. Research was supported by the Veterans Administration.


Dive into the research topics of 'Endogenous opiates and stress ulceration'. Together they form a unique fingerprint.

Cite this