TY - JOUR
T1 - Endocrine Complications of Cystic Fibrosis
T2 - A Multisystem Disease of the Endocrine Organs
AU - Ode, Katie Larson
AU - Chan, Christine L.
AU - Granandos, Andrea
AU - Putman, Melissa
AU - Moheet, Amir
N1 - Publisher Copyright:
© 2019 BMJ Publishing Group. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Cystic fibrosis (CF) is one of the most common life-limiting genetic disorders. Although CF is typically considered primarily as a pulmonary disease, the CF conductance transmembrane regulator is present throughout the body. From an endocrine perspective, this multisystem disease manifests primarily in the pancreas as a unique form of diabetes (CF-related diabetes mellitus), as bone disease, and as reproductive health issues in people with CF. These complications have become ever more concerning to people with CF as treatment for pulmonary disease improves and lifespans lengthen, increasing the impact of nonpulmonary complications. Our understanding of the management of these concerns continues to evolve, and, although there are some effective treatments, there is great opportunity for continued investigation into the pathophysiology of the endocrine complications of CF and their treatment.
AB - Cystic fibrosis (CF) is one of the most common life-limiting genetic disorders. Although CF is typically considered primarily as a pulmonary disease, the CF conductance transmembrane regulator is present throughout the body. From an endocrine perspective, this multisystem disease manifests primarily in the pancreas as a unique form of diabetes (CF-related diabetes mellitus), as bone disease, and as reproductive health issues in people with CF. These complications have become ever more concerning to people with CF as treatment for pulmonary disease improves and lifespans lengthen, increasing the impact of nonpulmonary complications. Our understanding of the management of these concerns continues to evolve, and, although there are some effective treatments, there is great opportunity for continued investigation into the pathophysiology of the endocrine complications of CF and their treatment.
KW - bone mineral density
KW - continuous glucose monitoring
KW - cystic fibrosis
KW - cystic fibrosis bone disease
KW - cystic fibrosis-related diabetes
KW - hypogonadism
KW - infertility
KW - insulin
UR - http://www.scopus.com/inward/record.url?scp=85077403954&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85077403954&partnerID=8YFLogxK
U2 - 10.1055/s-0039-1697917
DO - 10.1055/s-0039-1697917
M3 - Article
C2 - 31679155
AN - SCOPUS:85077403954
SN - 1069-3424
VL - 40
SP - 810
EP - 824
JO - Seminars in Respiratory and Critical Care Medicine
JF - Seminars in Respiratory and Critical Care Medicine
IS - 6
ER -