Endocrine Complications of Cystic Fibrosis: A Multisystem Disease of the Endocrine Organs

Katie Larson Ode, Christine L. Chan, Andrea Granandos, Melissa Putman, Amir Moheet

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Cystic fibrosis (CF) is one of the most common life-limiting genetic disorders. Although CF is typically considered primarily as a pulmonary disease, the CF conductance transmembrane regulator is present throughout the body. From an endocrine perspective, this multisystem disease manifests primarily in the pancreas as a unique form of diabetes (CF-related diabetes mellitus), as bone disease, and as reproductive health issues in people with CF. These complications have become ever more concerning to people with CF as treatment for pulmonary disease improves and lifespans lengthen, increasing the impact of nonpulmonary complications. Our understanding of the management of these concerns continues to evolve, and, although there are some effective treatments, there is great opportunity for continued investigation into the pathophysiology of the endocrine complications of CF and their treatment.

Original languageEnglish (US)
Pages (from-to)810-824
Number of pages15
JournalSeminars in Respiratory and Critical Care Medicine
Issue number6
StatePublished - 2019

Bibliographical note

Publisher Copyright:
© 2019 BMJ Publishing Group. All rights reserved.


  • bone mineral density
  • continuous glucose monitoring
  • cystic fibrosis
  • cystic fibrosis bone disease
  • cystic fibrosis-related diabetes
  • hypogonadism
  • infertility
  • insulin


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