Endocarditis caused by coagulase-negative staphylococci.

D. N. Williams, P. K. Peterson, J. Verhoef, M. Laverdiere, L. D. Sabath

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Sixteen patients with coagulase-negative staphylococcal endocarditis were treated at the University of Minnesota Hospitals between January 1970 and September 1977. In six patients, endocarditis developed after prosthetic valve surgery; among the other ten patients (the medical group), eight had known antecedent valvular disease. The skin was thought to be the source of infection in eight patients, suggesting that prompt treatment of skin infections and avoidance of injections in patients with valvular disease are important measures in the prevention of this disease. Patients with prosthetic valve endocarditis were infected with antibiotic-resistant organisms and had a higher mortality than those in the medical group (83% versus 20%). Bacterial isolates from three patients with prosthetic valve endocarditis were resistant to methicillin, and two of these three isolates also were resistant to cephalothin by quantitative susceptibility testing. The only patient with prosthetic valve endocarditis to survive was operated upon early in the course of his illness. These observation, coupled with the high mortality in this series and in others, has prompted us to advocate early surgery in prosthetic valve endocarditis.
Original languageUndefined/Unknown
Pages (from-to)5-9
Number of pages5
JournalInfection
Volume7
Issue number1
StatePublished - 1979

Keywords

  • Adolescent
  • Adult
  • Aged
  • Anti-Bacterial Agents/tu [Therapeutic Use]
  • Cephalothin/tu [Therapeutic Use]
  • Endocarditis, Bacterial/dt [Drug Therapy]
  • Endocarditis, Bacterial/et [Etiology]
  • Female
  • Heart Valve Diseases/co [Complications]
  • Heart Valve Prosthesis
  • Humans
  • Male
  • Methicillin/tu [Therapeutic Use]
  • Middle Aged
  • Penicillin Resistance
  • Postoperative Complications
  • Staphylococcal Infections

Cite this

Williams, D. N., Peterson, P. K., Verhoef, J., Laverdiere, M., & Sabath, L. D. (1979). Endocarditis caused by coagulase-negative staphylococci. Infection, 7(1), 5-9.

Endocarditis caused by coagulase-negative staphylococci. / Williams, D. N.; Peterson, P. K.; Verhoef, J.; Laverdiere, M.; Sabath, L. D.

In: Infection, Vol. 7, No. 1, 1979, p. 5-9.

Research output: Contribution to journalArticle

Williams, DN, Peterson, PK, Verhoef, J, Laverdiere, M & Sabath, LD 1979, 'Endocarditis caused by coagulase-negative staphylococci.', Infection, vol. 7, no. 1, pp. 5-9.
Williams DN, Peterson PK, Verhoef J, Laverdiere M, Sabath LD. Endocarditis caused by coagulase-negative staphylococci. Infection. 1979;7(1):5-9.
Williams, D. N. ; Peterson, P. K. ; Verhoef, J. ; Laverdiere, M. ; Sabath, L. D. / Endocarditis caused by coagulase-negative staphylococci. In: Infection. 1979 ; Vol. 7, No. 1. pp. 5-9.
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abstract = "Sixteen patients with coagulase-negative staphylococcal endocarditis were treated at the University of Minnesota Hospitals between January 1970 and September 1977. In six patients, endocarditis developed after prosthetic valve surgery; among the other ten patients (the medical group), eight had known antecedent valvular disease. The skin was thought to be the source of infection in eight patients, suggesting that prompt treatment of skin infections and avoidance of injections in patients with valvular disease are important measures in the prevention of this disease. Patients with prosthetic valve endocarditis were infected with antibiotic-resistant organisms and had a higher mortality than those in the medical group (83{\%} versus 20{\%}). Bacterial isolates from three patients with prosthetic valve endocarditis were resistant to methicillin, and two of these three isolates also were resistant to cephalothin by quantitative susceptibility testing. The only patient with prosthetic valve endocarditis to survive was operated upon early in the course of his illness. These observation, coupled with the high mortality in this series and in others, has prompted us to advocate early surgery in prosthetic valve endocarditis.",
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T1 - Endocarditis caused by coagulase-negative staphylococci.

AU - Williams, D. N.

AU - Peterson, P. K.

AU - Verhoef, J.

AU - Laverdiere, M.

AU - Sabath, L. D.

PY - 1979

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N2 - Sixteen patients with coagulase-negative staphylococcal endocarditis were treated at the University of Minnesota Hospitals between January 1970 and September 1977. In six patients, endocarditis developed after prosthetic valve surgery; among the other ten patients (the medical group), eight had known antecedent valvular disease. The skin was thought to be the source of infection in eight patients, suggesting that prompt treatment of skin infections and avoidance of injections in patients with valvular disease are important measures in the prevention of this disease. Patients with prosthetic valve endocarditis were infected with antibiotic-resistant organisms and had a higher mortality than those in the medical group (83% versus 20%). Bacterial isolates from three patients with prosthetic valve endocarditis were resistant to methicillin, and two of these three isolates also were resistant to cephalothin by quantitative susceptibility testing. The only patient with prosthetic valve endocarditis to survive was operated upon early in the course of his illness. These observation, coupled with the high mortality in this series and in others, has prompted us to advocate early surgery in prosthetic valve endocarditis.

AB - Sixteen patients with coagulase-negative staphylococcal endocarditis were treated at the University of Minnesota Hospitals between January 1970 and September 1977. In six patients, endocarditis developed after prosthetic valve surgery; among the other ten patients (the medical group), eight had known antecedent valvular disease. The skin was thought to be the source of infection in eight patients, suggesting that prompt treatment of skin infections and avoidance of injections in patients with valvular disease are important measures in the prevention of this disease. Patients with prosthetic valve endocarditis were infected with antibiotic-resistant organisms and had a higher mortality than those in the medical group (83% versus 20%). Bacterial isolates from three patients with prosthetic valve endocarditis were resistant to methicillin, and two of these three isolates also were resistant to cephalothin by quantitative susceptibility testing. The only patient with prosthetic valve endocarditis to survive was operated upon early in the course of his illness. These observation, coupled with the high mortality in this series and in others, has prompted us to advocate early surgery in prosthetic valve endocarditis.

KW - Adolescent

KW - Adult

KW - Aged

KW - Anti-Bacterial Agents/tu [Therapeutic Use]

KW - Cephalothin/tu [Therapeutic Use]

KW - Endocarditis, Bacterial/dt [Drug Therapy]

KW - Endocarditis, Bacterial/et [Etiology]

KW - Female

KW - Heart Valve Diseases/co [Complications]

KW - Heart Valve Prosthesis

KW - Humans

KW - Male

KW - Methicillin/tu [Therapeutic Use]

KW - Middle Aged

KW - Penicillin Resistance

KW - Postoperative Complications

KW - Staphylococcal Infections

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JF - Infection

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