Endocannabinoid-dependent synaptic plasticity in the striatum

Brady K. Atwood; David M. Lovinger

doi:10.1007/978-3-319-57371-7_5

Endocannabinoid-dependent synaptic plasticity in the striatum

Brady K. Atwood
, David M. Lovinger

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

The striatum plays a critical role in mediating the goal-directed and habitual behaviors involved in the development of drug abuse and addiction. Cannabinoid receptor-dependent synaptic plasticity is a prominent regulator of striatal circuit function. It is increasingly clear that striatal endocannabinoid signaling impacts the development of drug abuse. The expression of endocannabinoidmediated plasticity in the striatum is affected by disparate types of drugs of abuse, such as opiates and alcohol. Understanding the mechanism of endocannabinoidmediated plasticity and its effects on striatal circuit function may elucidate how endocannabinoids shape addiction-related behavior and perhaps offer new therapeutic avenues for treating drug abuse.

Original language	English (US)
Title of host publication	Endocannabinoids and Lipid Mediators in Brain Functions
Publisher	Springer International Publishing
Pages	109-153
Number of pages	45
ISBN (Electronic)	9783319573717
ISBN (Print)	9783319573694
DOIs	https://doi.org/10.1007/978-3-319-57371-7_5
State	Published - May 30 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© Springer International Publishing AG 2017. All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Publisher link

10.1007/978-3-319-57371-7_5

Find It

Find It at U of M Libraries

Cite this

@inbook{e424830e89994bbbb6fed5419ebb1993,

title = "Endocannabinoid-dependent synaptic plasticity in the striatum",

abstract = "The striatum plays a critical role in mediating the goal-directed and habitual behaviors involved in the development of drug abuse and addiction. Cannabinoid receptor-dependent synaptic plasticity is a prominent regulator of striatal circuit function. It is increasingly clear that striatal endocannabinoid signaling impacts the development of drug abuse. The expression of endocannabinoidmediated plasticity in the striatum is affected by disparate types of drugs of abuse, such as opiates and alcohol. Understanding the mechanism of endocannabinoidmediated plasticity and its effects on striatal circuit function may elucidate how endocannabinoids shape addiction-related behavior and perhaps offer new therapeutic avenues for treating drug abuse.",

author = "Atwood, \{Brady K.\} and Lovinger, \{David M.\}",

year = "2017",

month = may,

day = "30",

doi = "10.1007/978-3-319-57371-7\_5",

language = "English (US)",

isbn = "9783319573694",

pages = "109--153",

booktitle = "Endocannabinoids and Lipid Mediators in Brain Functions",

publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Endocannabinoid-dependent synaptic plasticity in the striatum

AU - Atwood, Brady K.

AU - Lovinger, David M.

PY - 2017/5/30

Y1 - 2017/5/30

N2 - The striatum plays a critical role in mediating the goal-directed and habitual behaviors involved in the development of drug abuse and addiction. Cannabinoid receptor-dependent synaptic plasticity is a prominent regulator of striatal circuit function. It is increasingly clear that striatal endocannabinoid signaling impacts the development of drug abuse. The expression of endocannabinoidmediated plasticity in the striatum is affected by disparate types of drugs of abuse, such as opiates and alcohol. Understanding the mechanism of endocannabinoidmediated plasticity and its effects on striatal circuit function may elucidate how endocannabinoids shape addiction-related behavior and perhaps offer new therapeutic avenues for treating drug abuse.

AB - The striatum plays a critical role in mediating the goal-directed and habitual behaviors involved in the development of drug abuse and addiction. Cannabinoid receptor-dependent synaptic plasticity is a prominent regulator of striatal circuit function. It is increasingly clear that striatal endocannabinoid signaling impacts the development of drug abuse. The expression of endocannabinoidmediated plasticity in the striatum is affected by disparate types of drugs of abuse, such as opiates and alcohol. Understanding the mechanism of endocannabinoidmediated plasticity and its effects on striatal circuit function may elucidate how endocannabinoids shape addiction-related behavior and perhaps offer new therapeutic avenues for treating drug abuse.

UR - https://www.scopus.com/pages/publications/85033593374

UR - https://www.scopus.com/pages/publications/85033593374#tab=citedBy

U2 - 10.1007/978-3-319-57371-7_5

DO - 10.1007/978-3-319-57371-7_5

M3 - Chapter

AN - SCOPUS:85033593374

SN - 9783319573694

SP - 109

EP - 153

BT - Endocannabinoids and Lipid Mediators in Brain Functions

PB - Springer International Publishing

ER -

Endocannabinoid-dependent synaptic plasticity in the striatum

Abstract

Bibliographical note

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this