Endobronchial involvement of mantle cell lymphoma

Mantle cell lymphoma (MCL) is the B-cell lymphoma with a poor prognosis. Most patients present with stage IV disease involving multiple sites. Although the thoracic involvement of non-Hodgkin lymphomas is common, isolated endobronchial involvement of MCL is extremely rare and, in fact, only 1 case has been described in the English Medical Literature. Here, we report a similar case of MCL with endobronchial involvement. Interestingly, both cases presented with shortness of breath and wheezing as a result of large masses in the large airways, trachea, and main bronchus, without mediastinal lymph node enlargement or parenchymal involvement. Early diagnosis with bronchoscopic sampling with local debulking procedures may improve survival by preventing airway compromise.