An efficient enantioselective synthesis of (-)-cytoxazone (1) and (+)-epi-cytoxazone (2) using proline-catalyzed asymmetric α-amino-oxylation of aldehydes followed by Rh-catalyzed diastereoselective oxidative C-H amination as the key steps is described. syn or anti 1,2-aminoalcohols were obtained by Rh-catalyzed intramolecular amidation of the C-H bonds of carbamates or sulfamate esters with good to excellent diastereoselectivity.
Bibliographical noteFunding Information:
N.V.S., T.S.K. and S.G. thank CSIR, New Delhi, for the award of research fellowships. The authors are thankful to Dr. B. D. Kulkarni, Deputy Director, for his support and encouragement.