Enantioselective synthesis of 3,4-dihydro-1,2-oxazepin-5(2 H)-ones and 2,3-dihydropyridin-4(1 H)-ones from β-substituted β- hydroxyaminoaldehydes

Keyphrases

• 1,4-addition 33%
• 2-substituted 33%
• 6-endo-dig Cyclization 33%
• Alcohol Oxidation 33%
• Aldehydes 33%
• Alkaloids 33%
• Alkyne Addition 33%
• Amino Acids 66%
• Amino Aldehydes 33%
• Broad Substrate Scope 33%
• Chirality 33%
• Cyclization 33%
• Enantioselective Synthesis 100%
• Enantioselectivity 66%
• Fmoc Deprotection 33%
• N-Boc 33%
• N-O Bond 33%
• One-carbon Homologation 33%
• Organocatalytic 66%
• Oxazepin 100%
• Protecting Groups 33%
• Proteinogenic Amino Acids 33%
• Reductive Cleavage 33%
• Tert-butyl 33%
• Tert-Butyldimethylsilyl 33%
• Unsaturated Aldehyde 66%

Chemistry

• addition to alkynes 33%
• Aldehyde 100%
• Amino Acid 66%
• Chirality 33%
• Enantioselective Synthesis 100%
• Organocatalysis 66%
• Protecting Groups 33%
• Proteinogenic Amino Acid 33%
• Reductive Elimination Reaction 33%