Abstract
Ribozyme-catalyzed Diels-Alder reactions: Through the use of either D- or L-ribozymes the absolute configuration of product 3 can be controlled. An ee value of > 95 % is reached in the reaction between 1 and 2. The hexaethylene glycol residue attached to 1 and 3 is an atavism that stems from the in vitro selection of the ribozyme. Reactions with substrates not containing this residue are also catalyzed, albeit with lower ee values.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4576-4579 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 39 |
| Issue number | 24 |
| DOIs | |
| State | Published - Dec 15 2000 |
Keywords
- Asymmetric catalysis
- Chiral recognition
- Cycloadditions
- Molecular evolution
- Ribozymes