Emerging technologies and ethics—exogenic chimeric humanized organs

Mary G. Garry, Arthur L. Caplan, Daniel J. Garry

Research output: Contribution to journalArticlepeer-review


Organ transplantation is limited due to the scarcity of donor organs. In order to expand the supply of organs for transplantation, interspecies chimeras have been examined as a potential future source of humanized organs. Recent studies using gene editing technologies in combination with somatic cell nuclear transfer technology and hiPSCs successfully engineered humanized skeletal muscle in the porcine embryo. As these technologies progress, there are ethical issues that warrant consideration and dialogue.

Original languageEnglish (US)
Pages (from-to)2786-2790
Number of pages5
JournalAmerican Journal of Transplantation
Issue number12
StatePublished - Dec 2022

Bibliographical note

Funding Information:
DJG is supported by grants from RMM and the DoD. MGG is supported by grant funding from the DoD. The authors have no other financial disclosures as described by the American Journal of Transplantation.

Publisher Copyright:
© 2022 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.


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